ASCP Hematology Review EXAM

Name the locations of active marrow in adults: - sternum, skull, ribs, pelvis, vertebrae Where does hematopoiesis take place during the first 2 months of gestation? - yolk sac Where does the majority of hematopoiesis take place during the 2nd through 7th month of gestation? - spleen When does the bone marrow take over hematopoiesis? - after birth What are the stages in order of the erythrocyte lineage? - (1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte, (5)reticulocyte, (6)erytrocyte What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil) lineage? - (1)myeloblast, (2)promyelocyte, (3)myelocyte, (4)metamyelocyte, (5)band, (6)segmented (7)eos/baso What are the stages in order of the macrophage lineage? - (1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage What are the stages in order of the platelet lineage? - (1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte, (4)platelet What are the stages in order of the lymphocyte lineage? - (1)lymphoblast, (2)prolymphocyte, (3)lymphocyte Which growth factors stimulate the erythrocyte lineage? - GM-CSF, EPO, IL-3 Which growth factors stimulate the granulocyte lineages? - GM-CSF, IL-3 Which growth factors stimulate the platelet lineage? - GM-CSF, IL-3, TPO Which growth factors stimulate the lymphocyte lineage? - IL-2, IL-4, IL-6, IL-7 Which protein functions in the transport of Fe? - transferrin What is the major storage form of Fe? - ferritin What is the long-term (H20) insoluble Fe storage form called? - hemosiderin Excess Iron is stored where? What does this cause? - tissues and body organs, hemosiderosis, hemochromatosis Porphyrias are attributed to? - excessive formation of porphrins due to blockages in any enzymatic step in the heme synthesis pathway. Red or port wine colored urine can be seen in which condition related to the build up of heme precursors? - porphyria Neuropsychiatirc symptoms are seen when a build up of which precursors occurs? - early precursors (Delta-aminolevulinic acid/Porphobilinogen) Cutaneous symptoms such as photo-sensitivity and facial hair are seen when a build up of which precursors occurs? - later precursors (uroporphyrinogen/coproporphyrinogen, protoporphyrin/heme)