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Samenvatting histo kraakbeen
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dit is uit het boek , slides, notities van patric calders
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H3KRAAKBEEN
Kraakbeen + bot + dentine (tand) = STEUNWEEFSEL
Plooibaar ( veel water) , niet bros
Geen bloedvaten
Geen zenuwen
Geen lymfevaten
- Type kraakbeen :
1) Hyalien kraakbeen
2) Elastisch kraakbeen
3) Fibrocartilago
1. Hyalien kraakbeen :
= vb kraakbeen v/d neus
- Cellen
Chondrocyten : actief mature
Ronde cellen
Grote centrale kern met veel nucleoli
Celoppervlak : veel uitstulpingen ( vergroot opp)
Cytoplasma: veel ribosomen , uitgebreid RER , Groot GOLGI-app veel
mitochondriën
Produceren extracellulaire matrix = glyproteïnen, …
Chondroblasten : jong
Elliptische cellen
Geen chondronen
, - Extracellulaire materiaal
Vezels:
Rechte structuren , vorming netwerk
Collageen 2 en (alfa 2)
Grondsubstantie:
Proteoglycanen : chondroïtinesulfaat/ keratansulfaaat : vormen
aggragaten vb hyluronzuur
- Perichondrium
= buiten laag = stamcellen = aangroeiing
Omgeeft het hyalien kraakbeen
Dichte laag bindweefsel
Fibroblasten ( mesenchymale cellen)
Kraakbeencellen
Hierin liggen bloedvaten , zenuwen , lymfevaten ( voeding)
- Voeding – Regeneratie
Voeding : diffusie ( chondrocyten : glycolytisch metabolisme)
Regeneratie : traag , ( vanuit het perichondrium )
2. Elastisch kraakbeen
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