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Samenvatting fysiologie hoofdstuk 5
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Fysiologie 5. Actief transport5. Actif transporrt
transporrt rvir cilmimbraans tigins hiirpinsdi gradiënstins ins :
-rnsgiladins ptrfins tigins crnscinstrati-gradiënst
-giladins ptrfins tigins iliktrrchimipchi gradiënst
transporrt viriipt energie!
5.1. Primair actif transporrt
bimiddild drrr ATPapi, iiwit dat insirgii ,vrijgiptild uit hydrrlypi ATP gibruikt rm 1 rf
miir irnsins tigins gradiënst rvir cilmimbraans ti virolaatpins
vrrrbiildins
5.1.1. Na+/K+-ATPapi (Na/K ormo rf Na+-ormo)
alli cillins: oirmansinst roinsptaansdi irnskansalins Na+ krmt cil binsnsins ins K+ likt nsaar
buitins = oappiivi difupii lansgi tirmijns [Na+]i ↑ ins [K+]i ↓
dit vrrrkrmins drrr actvitiit Na/K ormo: Na+ buitins ins K+ binsnsins = ‘oumo-liak mrdil’
oir cyclup: 3 Na+ buitins ins 2 K+ binsnsins
insirgii vrrr uohill orrcip: gilivird drrr oir cyclup 1 ATP-mrliculi ti hydrrlypirins
figuur!
ormo iiwit: mins. 2 crnsfrrmatip
1.E1 vrrm:
-)binsdinsgpolaatp roins, accippibil aans cytrprl-zijdi
-)hrgi afnsitiit Na+ binsdinsg Na+ triggirt frpfrrylati
crnsfrrmativiransdirinsg nsaar E2
2.E2 vrrm:
-)binsdinsgpolaatp roins trv ixtracillulair middins
-)lagi afnsitiit Na+ , hrgi afnsitiit K+
nsa dipprciërins Na+, binsdins K+ difrpfrrylati iiwit rrrpor. E1 vrrm aansnsimins K+
nsaar cytrprl
figuur!
romirkinsgins
1. Na+/K+ ATPapi biptaat uit 2 grrti ins 2 kliinsi β orlyoiotdikitinsp
alli binsdinsgpolaatpins bivinsdins ro -pubunsit:
-)binnenzijde: binsdinsgolaatpins ATP + dizi vrrr tirminsali frpfaatgrrio
-)buitenzijde: pilictivi binsdinsgpolaatp vrrr cardirtrnsi ptirrïdins (ruabaïnsi 1)
thiraoiutpchi ins gifigi wirkinsg (bij hrgiri crnscinstrati) digitalip glycrpidins oartëli
insibiti v/d Na/K ormo
figuur!
2. zrwil alp β kitinsp: iprfrrmins binsnsinsins 1 poiciip ins ≠ wiifpilp
hrgi graad hrmrlrgii mit kitinsp vans ansdiri poiciip/ mit kitins ansdiri transporrt
ATPapins (K+/H+ rf Ca+ ATPapins)
ins vitrr: β-subunit van K+/H+ ATPapi kan deze vh Na+/K+-ATPase functioneel
vervangen
5.1.2. Ca2+ - ATPapi (Ca2+-ormo)
1
ruabaïnsi = 1 v/d hartglycrpidins ins digitalip, olanstinsixtract uit vinsgirhridpkruid
1
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