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Final Exam Review UNE Medical Biochemistry – Q&A
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Final Exam Review UNE Medical Biochemistry – Q&AUnder fasting conditions (ratio of insulin: glucagon <1), elevated glucagon
will activate which of the following enzymes? Correct Ans -
hormone sensitive lipase
Ketonuria, hypoglycemia, and severe acidosis are prime diagnostic
indicators of the presentation of type 1 diabetic ketoacidosis. Which of the
following compounds are "ketone bodies" that would be elevated in serum
of urine of a patient in this condition? Correct Ans - D-3-
hydroxybutyrate and acetoacetate
What is the purpose of cholesterol esterification within the cell? (the
conversion of cholesterol to cholesteryl ester)
a. this modification makes cholesterol more soluble in the plasma
membrane
b. this modification does not change the chemical properties of cholesterol
c. esterification is the first step in the synthesis of cortisol
d. esterification traps cholesterol in the cell Correct Ans -
esterification traps cholesterol in the cell
An individual goes to bed around 8 pm and doesn't wake up until 9 am the
next morning. During this time, which of the following is the primary
oxidizable substrate in the skeletal muscle?
a. free fatty acids
b. glycogen
c. amino acids
d. lactate Correct Ans - free fatty acids
A 22-year-old woman engaging in a political protest goes on a hunger
strike on a prominent corner in a city park. She refuses all offers of food for
except for water through the first 2 weeks. Under these conditions there is
a decreased reliance on which of the following pathways for fuel?
a. β-oxidation
b. ketogenesis
c. gluconeogenesis
d. lipolysis Correct Ans - gluconeogenesis
, In reverse cholesterol transport HDL interacts with the ABCA1 transporter
to move cholesterol from the cell to the HDL. This also requires the activity
of which of the following enzyme?
a. lipoprotein lipase
b. cholesteryl ester transfer protein (CETP)
c. lecithin cholesterol acyltransferase (LCAT)
d. LDL receptor Correct Ans - lecithin cholesterol acyltransferase
(LCAT)
A 16-year-old woman presents to her primary care physician for a follow
up visit. At her initial visit, 3 months ago, her serum cholesterol was 255
mg/dL (above normal). She finds this very disappointing as she started a
strict dietary regime reducing all fats and cholesterol, replacing them with
a high carbohydrate diet. You tell her that high carbohydrate diets can
increase serum triglyceride levels in some individuals. This can be
attributed in an increase in the synthesis of which of the following
lipoproteins?
a. chylomicrons
b. VLDL
c. IDL
d. HDL
e. LDL Correct Ans - VLDL
a 5-year-old presents to her primary care physician. Her mother is
concerned due to persistent diarrhea which is worse when eating fatty
foods. The child also has some clinical signs of a deficiency in fat-soluble
vitamins. Based on this information the child likely has a deficiency in the
ability to synthesize which of the following lipoproteins?
a. chylomicrons
b. VLDLs
c. LDLs
d. HDLs Correct Ans - chylomicrons
The interaction of chylomicorns with lipoprotein lipase is stimulated by
which of the following Apo proteins?
a. ApoB 100
b. Apo B 48
c. Apo C II
d. Apo E Correct Ans - Apo C II
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