Condensed class notes summarizing lectures about pH and pKa relating to biochemistry. Includes pH, pKa, Henderson-Hasselbach equation, buffer zone, and titration curves. Contains illustrations and diagrams.
Acidic Basic/ALKALINE
-
6-
5
↓
HAs A PH of 2 THE
Example : LEMON
joice <6 5 NEUTRAL 7 54
↳
. . .
6 5-7 5
.
.
CONCENTRATion of [Htj is 1
.
0x103 M
Buffers find CHt] and [AS
BufferingRange-the
& TiTratton curve Below Can Be used to THE Ph WHERE are
This is THE PKa HOWEVER PKaEI This is due BuffERS Acid BASE RESIST
Equal Changes
A WEAK tiTS
Conjugate
.
. THERES An Allowance : .
TO
,
Buffers Are Essential from
Brozog
TOCH] & [A-]
Biolog Damag
in THE PROTECT ICAL Molecules
Range
WITHIN A CERTAIN .
.
7
Due Pt
L Histidine And Buffers
changes
Extreme in Appare oud As
They
To
g
.
CAN Exist As PROTONATEd or DEPROTONATED Al Physio iCAL PH
9
Bonging
Acidosis Blood Acidic Blood plasma Buffered
: is 700
>
-
-
is
By
ALKALOSIS : Blood S Too Basic THE BICARBONATE SYSTEM
# HCO3HeCOzT HOt C
*
PROTON
Production of HyCO3
PROTON
CAN BE Acceptor DONOR
of
By
RegulatingExchange COzig) (Bresting
MANPUAED
Acidosis - increase of CO2 , Body [CO2]
Lowering
Exalation in THE .
ALKALOSIs- Slow [202]
Breathing
Rate TO increase
I
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