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Class notes

Thermodynamics for Biochemistry - Biochemistry

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Condensed class notes for lectures about thermodynamics for biological sciences. Includes entropy, hydrophobic effects, protein folding , and Gibbs free energy.

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  • January 18, 2024
  • 2
  • 2023/2024
  • Class notes
  • Dustin king
  • Class 2 to 3
avatar-seller
THER
MODYNAMICS




E
ANABOlic A


livinggEnergy Exciting
Arrosm is an in THAT o Can
open System



· Surroundings
master mod mos




AH
atzing
A could BE : =
Ein
System Enthalpy
-

I
A Brochemical RXN MEASURES How Much
-




Energy
is



PATHWAY REgUrrED By
-


A METABOLIC A
process .




Lost Heat
SSS & -


An individual cell AHO is Favourable

↳· ·
A WHOLE THE Of OH DETERMINED
By
-

VIVE
Organism
L
Is

·
8 ↑⑳
o -
S
-



of Bonds As

L

v
THE
N umber WELL As
--
·
Biods for BONd Types
Building
. MEASURED In JONES .




Biosynthesis

AS of Disorder AH <0
chang System LosEs HEA
=
Ein
Entropy Entropy is a Measure
-




OR RANDOMNESS "THE .
UNNERSE TENdS TOWArd CHAOS" An INCREASE
. In
Entropy is =
ExOTHERMIC


THERMODYNAMICALLY FAVOURABLE WHE A dECREASE In Enropy is Not . RECALL
MOLECUTES
NORPOLAR
IN WHER
AHO
SYSTEM TAKES HEAL from
of
Surrardnungs
WHEN A
SYSTEM RELEASES HEAT , i RANSES THE Entropy THE

=
Would Be of composer Endothermic
Surroundings
A SIMILAR CASE The

Aggreghrow
.



MOLECULES WATER : WHOLE THE is a decrease
Aggregation
In


... of the HO
↑ &




· surrounding
o
.
-
Evropy The
in morecues
· emropy
:
.
.....
②.... "no"
E
· ,

·




·
- 86 --- ....
%e



..........
...
-
g

:
INCREASES As MOTOw is LESS RESTRICTED




Biological Thermodynamics
folding
THERMODYNAMICS Of PROTEIN




·
·
Hydrophilic
·
Hydrophobic

proteins Hate
&

High
Evropy


[
WATER HAS LOW
Entropy
- Due To
Hydrophobic
Effects

SO S> E
WHER
PROTEINS




·mon
o· High Entropy
WATER Has




·
· ·
D
000
%

.00 .


⑧ ·o
· Proteins Have
· S Low
entropy

·





·...
&
o
o
·

-

- o





WATER AS7O PROTEINS ASSO

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