Bilateral oophorectomy prior to age 45 increases risks for: - ✔️ - All
cause mortality
- Coronary heart disease
- CVD
- Menopause symptoms
- Worsening mood symptoms
- Higher incidence of Parkinson Disease
- Associated with cognitive impairment
Early Menopause Transition (-2) - ✔️ 7 or more days persistent
difference in cycle length from previous normal cycle
- Results of increased follicular aging and depletion
- Inhibin B decreases
- FSH increases (Variable)
LOOP Cycles - ✔️ Explains elevation of Estradiol in perimenopause
- Rising FSH levels recruit 2nd follicle during luteal phase which leads to
overproduction of Estradiol
- This causes menstrual changes in future cycles
Decreased AMH in Early Menopause Transition - ✔️ More frequent
anovulatory cycles
Decreased Inhibin B in Early Menopause Transition - ✔️ - Skipped
menstrual cycles
- Mastalgia
- Migraine
- Menorrhagia (with LOOP cycles)
- Endometrial Hyperplasia
Late Menopause Transition (-1) - ✔️ 60 or more days of amenorrhea for
women aged 45 years or older
, - Women 40-44 years with recurrent episodes of amenorrhea of 60 day for
longer within a year improves prediction of entry into late menopause
transition
Late Menopause Transition (-1) Duration - ✔️ 1-3 years
Late Menopause Transition (-1) Symptoms - ✔️ VMS likely
STRAW Stage where FSH > 25 - ✔️ Late Menopause Transition (-1)
Elevated FSH symptoms in Late Menopause Transition - ✔️ - VMS
- Sleep disturbance
- Changes in weight distribution
- Increased variability in cycle length
Decreased Inhibin B in Late Menopause Transition - ✔️ - Mood changes
- Cognitive complaints
- Changes in sexual functioning
- Increased prevalence of anovulation
Decreased AMH in Late Menopause Transition - ✔️ - GSM
- Bone loss
- CVD issues
- Interval of amenorrhea > 60 days
POI - ✔️ Menopause before age 40
POI diagnosis - ✔️ - Oligomenorrhea or amenorrhea x 4 months
- FSH > 25 on two occasions at least 4 weeks apart
POI Symptoms - ✔️ - Hot flashes
- Mood changes - depression
- Insomnia
- Vaginal dryness, dyspareunia
POI Management - ✔️ HT until average of menopause
Early Menopause Risks (natural or surgical) - ✔️ - CVD
- Low bone density
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller LeCrae. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $12.99. You're not tied to anything after your purchase.