Samenvatting Immunologie schema's CD's, cytokines en interleukines
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Course
Immunologie
Institution
Universiteit Antwerpen (UA)
Het is vaak moeilijk om een overzicht te bewaren tussen alle verschillende CD's, cytokines en interleukines. Daarom heb ik een overzichtelijk schema gemaakt waarbij alles nog eens duidelijk op een rijtje wordt gezet.
CD Oorsprong functie Afbeelding
CD34 (HPCA-1) Stamcellen, alle hematopoëtische Adhesiemolecule matrix
cellen
CD14 (TLR4-LPS) Macrofagen PRR: patroonherkenningsreceptor (herkent
LPS)
MHCI Alle somatische cellen met kern Presenteert antigenen aan CTL
MHCII Op APC Antigenen presenteren
CD16 (ADCMC) NK-cel Antibody dependent mediated cytotoxicity (Fc
receptor)
CD56 NK-cel
CD11/18 NK-cel Adhesie
CD2 NK-cel Adhesie
CD4 Thc Coreceptor voor TcR met MHCII
CD8 NK-cel, cytotoxische T-lymfocyt Coreceptor voor TcR met MHCI
CD95 (FAS) Geïnfecteerde cel Via CD95L NK-cel/CTL → activatie caspase 8 →
apoptose
, CD80/86 APC Activeren CD28 bij Ag-presentatie
Activeren CTLA-4 : inhiberend effect
CD28 Tc Geactiveerd door CD80/86
CTLA-4 Tc Geactiveerd door CD80/86: inhiberend effect
CD40 APC en B-lymfocyt T-cel: CD40 activeert CD40L bij Ag-presentatie
B-cel: Isotype switch B-lymfocyten
CD40L (CD154) T-lymfocyt
CD3 T-cellen Merker voor alle T-cellen (geen NK!)
Signaal transducer TcR
CD4, CD25, foxp3, CD127 Treg regulatie
CD79a/CD79b B-cel Signaaloverdracht
CD19 B-cel B-cel coreceptor
CD81 B-cel B-cel coreceptor
CD21 B-cel, DC CR2 → C3d → B-cel coreceptor
CD45 Alle leukocyten CD45RA: naïeve T-cellen
CD45RO: geheugen T-cellen
CD35 Bly, DC, MF, neutro, RBC CR1, fagocytose
CD11b/18 Neutro, MF, DC CR3, fagocytose
CD11/18 Neutro, MF, DC CR4, fagocytose
CD1 T-cel Aanbieden lipiden
CCR7 B-cel Geactiveerde B-cel, kan communiceren met T-
cel Naïeve B-cel: CXCR5
CD27 Plasmacel merker
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