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Neuropsychology College Notes (P_BNEUROP)

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Neuropsychology lecture notes, bachelor psychology year 2

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  • January 24, 2024
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Hoorcolleges Neuropsychologie | Anouk Wiersma



Neuropsychologie
Uitwerking hoorcolleges

Lecture 1: Introduction & the neuropsychologist
- The brain
o Grey matter: neurons
o White matter: myelin
o 4 lobes divided by sulci; frontal, parietal, occipital and temporal lobes.
o Limbic system: hypothalamus (homeostasis), thalamus (relays information), amygdala
(emotion), and hippocampus (memory conversion).
o Ventral and dorsal stream of vision.
 Ventral: from occipital lobe to temporal lobe.
 Dorsal: from occipital lobe to parietal lobe.
- Brain location and vocabulary




o




o

- Brain lesions

, Hoorcolleges Neuropsychologie | Anouk Wiersma


o Area of brain damage
o Can result from stroke, loss of blood flow, tumor, injury, etc.

- Principles of brain organization
o Clinical cases of brain lesions led to the discovery that certain types of damage were
consistent with certain types of symptoms.
 Localization: damage was in a certain part of the brain  concluded that
some brain functions were anatomically located.
 Lateralization: damage was on a certain side of the head  concluded that
some functions were usually on a specific side of the brain.
 Distribution of function: lost functions are sometime rehabilitated 
concluded that other parts of the brain can compensate.
 Hierarchical organization: sophistication of functions very depending on
whether a ‘higher’ or ‘lower’ brain area was damaged  brain processes
start with lower levels and are processed through increasingly higher levels.
 Organization: hindbrain  midbrain  forebrain (from basic to more
sophisticated).
 Processing begins with lower brain regions and then moves on to
higher regions.
 Loss of function in higher brain regions (forebrain) = dissolution
(brain can compensate with lower regions, simplified behavior).

- History of neuropsychology
o Donald Hebb – father of neuropsychology
 Hebbian theory: neural pathways develop based on experiences; as pathways
are used more, they become faster and stronger.
 ‘Use it or loose it’.
 Hebbian assumptions of change: environment, culture, customs, family
history, lifestyle, and more shape who we are.
 Fundamental properties of the brain: plasticity, flexibility, and
adaptability.

- Neurological examination
o Patient’s history
o State of awareness
 Alert, drowsy, stupor, confused.
 Speech abnormalities, facial asymmetries, body posture.
 Emotions.
o Physical examination
 Blood pressure, brain imaging, reflexes, pain, muscle movement, smell, etc.
o Disorders
 Stroke, injuries and lesions may show asymmetry, loss of function.
 Parkinson’s may show loss of smell and motor changes.
 Dementia may show memory loss, disorientation, or agitation.
o  Biopsychosocial model changes neuropsychology
 Both biological, psychological and social circumstance influence mental
health.
 Social support networks.
 Patients’ sense of wellbeing.
 Sometimes a mismatch between the patients’ needs and their social network
or environment can add stress that may impair healing.

, Hoorcolleges Neuropsychologie | Anouk Wiersma


- Genetics and the brain
o Stress and epigenetics
 Stress have larger biological consequences than originally thought 
Lamarckian theory, section 1.2.
 Stress can influence epigenetic changes and mental health.
o Behavior is caused by genetics, epigenetics, and experience-based learning.

, Hoorcolleges Neuropsychologie | Anouk Wiersma



Lecture 2: The neuron
- Multiple Sclerosis (MS)
o MS is caused by damaged myelin.
o Cumulative damage produces brain lesion.
o MS is a heterogenous disorder = patients have different symptoms & experiences
depending on lesion size and locations, and how their individual brain is functionally
organized.
o MS affects brain and spinal cord.
o Common symptoms:
 Muscle spasms, stiffness, weakness, or paralysis.
 Mobility problems.
 Numbness / tingling sensations, pain.
 Speech and swallowing difficulties.
 Vision problems.
 Sexual problems.
 Bladder or bowel problems.
 Fatigue.
 Difficulties thinking, learning, and/or planning.
 Depression and anxiety.
o Types of MS
 Primary progressive (PPMS): symptoms onset and
progressively get worse. No history of remission.
 Relapsing remitting (RRMS):
 Relapse = active symptoms / myelin
damage.
 Remission = no current symptoms / myelin
damage.
 Symptoms disappear and reappear across time.
 Progressive relapsing (PRMS): similar to RRMS, but symptoms become
increasingly disabling with each relapse.
 Very rare, very disabling.
 Secondary progressive (SPMS): occurs after patient previous had SPMS,
remission stops, symptoms get steadily worse.
o Affected neurons
 Immune cells attack the myelin sheath.
 Exposed axon is scarred.
 Information transmitted by that neuron is disrupted.

- The neuron – nerve cells
o Electrical and chemical signals pass from the axon terminal of one neuron to the
dendrites of the next neuron.
o Cell body / soma = grey matter.
o Myelin sheath = white matter.
o Many types of neurons
 Unipolar neuron: not in the human body.
 One extension form the cell body,
containing one axon with dendrites at its
tip.
 Bipolar: rare  in ear, nose and eye.

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