Class notes
pathology 3500 hemophilic disease 1 notes
- Course
- Institution
Notes for pathology 3500 hemophilic disease 1 notes. Lecture notes, not prof notes
[Show more]
Seller
Follow
kyuju
Content preview
PATH3500NOV 13: HEMATOLYMPHOID PATHOLOGY 1
Objectives
1. RBCs
a. Describe cellular components of blood, their origins & principal functions
b. Define & discuss symptoms + signs of anemia
c. Explain how anemia’s classified & list common causes of anemia in context of these
classifications
2. WBCs
a. Outline common causes of reactive leukocytosis + neutropenia w/ examples
b. Classify + briefly discuss main groups of white cell malignancies – lymphoid + myeloid
neoplasms, leukemia, as to age groups affected, clinical presentation + prognosis
3. Bleeding disorders
a. Briefly discuss main causes of bleeding disorders
Part 1: Hematopoietic – introduction
- Even though blood’s a fluid structure + not officially an organ, actually one of more most critical
system in body bc every single other organ relies on it
Normal blood cells
- RBC is anucleate (i.e. no nucleus)
o Lighter link inside is hemoglobin (main compound in cell); central pallor
- Platelet, also doesn’t have nucleus
o Chunk of cytoplasm broken off from megakaryocyte in bone marrow
o 2nd most common cell
- Granulocyte
o Granular cytoplasm, i.e. there’s granules present in cytoplasm
o Most common is neutrophil or polymorphic leukocyte
o Eosinophil – red granules
o Basophil – dark blueish granules
- WBC
o Biggest is monocyte w/ pale blue cytoplasm + vacuoles (often doesn’t have any)
▪ Oval or bean-shaped nucleus
o Lymphocytes - most boring looking cells of WBCs but most intelligent bc do important
job
, Cellular components of blood: bone marrow origin
- All prev mentioned are derived from bone marrow; have pluripotent potential stem cells
o w/ greater # of differentiation events, become less able to differentiate until it forms a
committed stem cell (2 main ones, myeloid or lymphoid)
o Lymphoid stem cells form lymphocytes (T-cells, B-cells, NK cells)
o Myeloid stem cells form all other cells
Main functions of blood cells
- Very simple functions
o RBC – transport oxygen in blood + CO2 back from tissues into lungs
o WBC – prevent infection in body + foreign invasion
o Platelets – preserve integrity of blood vessels by forming platelet plugs + participating in
coagulation
How we approach blood cell disorders?
- Either have too many or too little blood cells
o To determine, huge # of people are measured & w/ machine, # of RBCs, WBCs + platelets
are counted
o Then look at huge population of people, take average or range of average + called
‘enough’ of blood cells present (i.e. right amount)
Part 2: RBCS – anemia
Disorders of red cells: anemia
- Anemia = too few RBCS, polycythemia = too many RBCs
o Polycythemia not huge problem in practice; big topic for discussion so will focus on
anemia
- Physically leads to decrease in oxygen-transporting ability of blood due to decreased # (or
function) of circulating RBCs
o What RBCs do, i.e. transport oxygen
- In complete blood count (CBC), anemia’s most commonly determined by decrease in
hemoglobin concentration
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller kyuju. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67866 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now