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Samenvatting WBC + trombocyten - Hematologie
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Samenvatting hematologie 2 deel WBC + trombocyten uit academiejaar
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HEMATOLOGIE 2:WBC + TROMBOCYTEN
Lector. Flies Reinoud
2023 - 2024
,INHOUD
Inleiding................................................................................................................................................................... 3
1. Granulocyten ....................................................................................................................................................... 5
1.1 Neutrofiele granulocyten .............................................................................................................................. 8
1.2 Pathologiën ................................................................................................................................................. 11
1.3 Eosinofiele granulocyten ............................................................................................................................. 13
1.4 Basofiele granulocyten ................................................................................................................................ 16
2. Monocytopoeise ............................................................................................................................................... 17
2.1 Inleiding ....................................................................................................................................................... 17
2.2 Ontwikkeling in beenmerg .......................................................................................................................... 17
2.3 Morfologie van de monocyten .................................................................................................................... 17
2.4 Distributie van de monocyten en macrofagen in het lichaam .................................................................... 18
2.5 Receptoren .................................................................................................................................................. 18
2.6 Antigenen .................................................................................................................................................... 18
2.7 Werking ....................................................................................................................................................... 19
2.8 Antigen presentatie ..................................................................................................................................... 20
2.9 Monocytose ................................................................................................................................................ 20
3. Lymfopoiese ...................................................................................................................................................... 21
3.1 Lymfopoiese ................................................................................................................................................ 22
3.2 Ontwikkeling van de lymfocyten ................................................................................................................. 22
3.3 Lymfocyten .................................................................................................................................................. 23
3.4 B-lymfocyten ............................................................................................................................................... 24
3.5 T-lymfocyten ............................................................................................................................................... 26
3.6 Samenwerking tussen B- en T-lymfocyten .................................................................................................. 27
3.7 Natural Killer Cellen ..................................................................................................................................... 28
3.8 Lymfocytosen .............................................................................................................................................. 29
4. Niet maligne afwijkingen van de witte bloedcellen .......................................................................................... 30
4.1 Mononucleosis syndromen ......................................................................................................................... 30
4.2 Mononucleosis infectosa ............................................................................................................................ 30
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Moons N
, 4.3 Cytomegalocirus CMV ................................................................................................................................. 31
4.4 Toxoplasmose ............................................................................................................................................. 31
5. Trombopoiese ................................................................................................................................................... 32
5.1 Endomitose ................................................................................................................................................. 32
5.2 Plaatjesproductie ........................................................................................................................................ 32
5.3 Trombocyten / bloedplaatjes ...................................................................................................................... 33
6. Hematologie in de practijk ................................................................................................................................ 36
6.1 Witte Bloedcellen ........................................................................................................................................ 36
6.2 Rode Bloedcellen ......................................................................................................................................... 36
6.3 Bloedplaatjes ............................................................................................................................................... 37
6.4 Malaria : dikdruppel .................................................................................................................................... 37
6.5 Differentiaaltelling WBC .............................................................................................................................. 38
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, INLEIDING
• WBC zijn van cruciaal belang voor afweer tegen ziekteverwekkende micro-organismen
• #WBC : 4 000 – 11 000 /µl
• Oorsprong in stamcel → verder uitrijpen / differentiëren naar verschillende cellen
Hematopoiese = het proces waarbij de verschillende bloedcellen worden aangemaakt
Neutrofiele
granulocyten
Eosinofiele
Granulopoiese
granulocyten
Basofiele granulocyten
Myelopoiese Monocytopoiese Monocyten/macrofaag
Trombopoiese Trombocyten
Hematopoeise
Erytropoiese RBC
Lymfopoiese T- en B- lymfocyten
Myelopoiese = aanmaak van alle cellen die in het beenmerg worden aangemaakt
Lymfopoiese = aanmaak van lymfocyten deels in beenmerg en deels in lymfatisch weefsel
Pluripotent stem cell
= stamcel die nog naar verschillende
cellen kan omvormen
CFU = Colony forming unit
= tussengroep van cellen in het
beenmerg die we nog niet kunnen
herkennen
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Moons N
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