Nuclear Medicine Board Review Questions & Answers (Graded A)

Gas Ventilation - ANSWER-Xe 133, 81 KeV, 5.3 half life; reactor produced dose: 10-20 mCi imaging: posterior position negative pressure room required uses activated charcoal trap to accumulate the exhaled xenon gas until decayed to background single breath: during inhalation wash in / equilibrium : collected while the xenon distributes through aerated portions of the lung wash out : while radioactivity is cleared from lungs Sr 89 Chloride - ANSWER-Strontium Chloride, Metastron 1.46 MeV max, .58 Mev mean half life = 50.5 days 40-60 uci/kg IV for skeletal mets, depresses bone marrow shouldn't be used if leukocyte count below 2400/ul or platelet below 60,o00/ul excretion : urinary I 131 Tositumomab - ANSWER-Bexxar half life = 8.04 days 606.3 KeV max energy treatment of patients with NHL before treatment, patient must receive 650 mg acetaminophen and 50mg diphydramine orally thyroid uptake should be minimized with SSKI activity initially seen in blood pool, liver and spleen later times, activity in liver, spleen, thyroid, bladder, and tumor sites Y 90 ibritumomab tiuxtetan - ANSWER-Zevalin half life = 2.67 days 2.281 MeV treatment of patients with NHL (disseminated follicular B-Cell) monoclonal antibody against lymphoma antigens before treatment, patient must receive 650 mg (imaging) acetaminophen and 50mg diphydramine orally max dose = 32 mci platelets must be at least 100,000/mm3 Sm 153 EDTMP - ANSWER-ethylenediaminetetra methylene phosphonic Quadramet half life = 46.7 hours 0.81 MeV maximum concentrates in bone marrow for patients with more metabolically activate metastases from prostate or breast cancer, as well as those from osteogenic sarcoma 1.0mci/kg urinary excretion Bone therapy blood requirements - ANSWER-60,000-100,000/ul platelet /ul leukocyte 2000/ul granuolyte I 131 MIBG - ANSWER-metaiodobenzylguanidine half life = 8.06 days localization/treatment of primary or metastatic pheochromocytomas/ neuroblastoma 8.04 days kidney/ urinary excretion I 131 Sodium Iodide - ANSWER-half life = 8.06 days used to treat hyperthyroidism, thyroid carcinoma 10-15