NURS 472 NURSING PHARMACOLOGY 100+ EXAM QUESTIONS AND CORRECT ANS 2024 UPDATE
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Course
NURSING PHARMACOLOGY
Institution
NURSING PHARMACOLOGY
What are the major functions of the α1 receptor? - Increase vascular smooth muscle contraction, increase pupillary dilator muscle contraction (mydriasis), increase intestinal and bladder sphincter muscle contraction
What are the major functions of the α2 receptor? - Decrease sympathetic outflo...
What are the major functions of the α1 receptor? - Increase vascular smooth muscle contraction,
increase pupillary dilator muscle contraction (mydriasis), increase intestinal and bladder sphincter
muscle contraction
What are the major functions of the α2 receptor? - Decrease sympathetic outflow, decrease insulin
release, decrease lipolysis, increase platelet aggregation, decrease aqueous humor production
What are the major functions of the β1 receptor? - Increase heart rate, increase contractility, increase
renin release, increase lipolysis
What are the major functions of the β2 receptor? - Vasodilation, bronchodilation, increase lipolysis,
increase insulin release, decrease uterine tone (tocolysis), ciliary muscle relaxation, increase aqueous
humor production
What are the major functions of the M1 receptor? - CNS, enteric nervous system
What are the major functions of the M2 receptor? - Decrease heart rate and contractility of atria
What are the major functions of the M3 receptor? - Increase exocrine gland secretions (e.g., lacrimal,
salivary, gastric acid), increase gut peristalsis, increase bladder contraction, increase
bronchoconstriction, pupillary sphincter muscle contraction (miosis), ciliary muscle contraction
(accommodation)
What are the major functions of the D1 receptor? - Relaxes renal vascular smooth muscle
What are the major functions of the D2 receptor? - Modulates transmitter release, especially in the
brain
,What are the major functions of the H1 receptor? - Increase nasal and bronchial mucus production,
increase vascular permeability, contraction of bronchioles, pruritis, pain
What are the major functions of the H2 receptor? - Increase gastric acid secretion
What are the major functions of the V1 receptor? - Increase vascular smooth muscle contraction
What are the major functions of the V2 receptor? - Increase H2O permeability and reabsorption in
collecting tubules of kidney (V2 is found in the "2" kidneys)
What receptors are associate with Gq? - H1, α1, V1, M1, and M3
What receptors are associated with Gs? - H2, B1, B2, V2, D1
What receptors are associated with Gi? - M2, α2, D2
Bethanechol - -Direct cholinergic agonist
-Activates bowel and bladder smooth muscle
-Used in postoperative and neurogenic ileus
-Resistant to AChE
Carbachol - -Direct cholinergic agonist
-Carbon copy of acetylcholine
-Constricts pupils and relieves intraocular pressure in glaucoma
Methacholine - -Direct cholinergic agonist
-Stimulates muscarinic receptors in airways when inhaled
-Historically used to diagnose myasthenia gravis (MG is now diagnosed by anti-AChR Ab test.
Neostigmine - -Anticholinesterse - increases ACh
-Used in postoperative and neurogenic ileus and urinary retention, myasthenia gravis, and postoperative
reversal of neuromuscular junction blockade
Physostigmine - -Anticholinesterse - increases ACh
-Used in anticholinergic toxicity
-Crosses the blood-brain barrier (CNS)
Pyridostigmine - -Anticholinesterse - increases ACh
-Increases muscle strength
-Used in myasthenia gravis (long acting)
, -Does not penetrate CNS
Atropine - -Muscarinic antagonist
-Used in bradycardia and for ophthalmic applications
-Also used as antidote for cholinesterase inhibitor poisoning
-Actions include increase pupil dilation, cycloplegia, decreased airway secretions, decreased acid
secretions, decreased gut motility, decreased bladder urgency in cystitis
-Toxicity: increased body temp (due to decreased sweating), rapid pulse, dry mouth, dry and flushed
skin, cycloplegia, constipation, disorientation;
-Can cause acute angle-closure glaucoma in elderly (due to mydriasis), urinary retention in men with
prostatic hyperplasia, and hyperthermia in infants
-See also homatropine and tropicamide
Benztropine - -Muscarinic antagonist
-Works in CNS
-Used in Parkinson disease and acute dystonia
Glycopyrrolate - -Muscarinic antagonist
-Parental use: preoperative use to reduce airway secretions
-Oral use: drooling, peptic ulcer
Hyoscyamine - -Muscarinic antagonist
-Antispasmodics for IBS
Dicyclomide - -Muscarinic antagonist
-Antispasmodics for IBS
Ipratropium - -Muscarinic antagonist
-Used in COPD and asthma
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