Class notes
Peptic Ulcer Treatment
- Course
- Institution
- Book
Medicine notes on peptic ulcers
[Show more]
Connected book
Book Title:
Author(s):
- Edition:
- ISBN:
- Edition:
More summaries for
-
Cancer Treatments. Kumar&Clark's. Bachelor Medicine, Geneeskunde (RUG) - 2.1.3. Neoplasms
-
Clinical Medicine Ch. 23, 24 - Acute Respiratory Diseases
-
Diseases of the heart and large blood vessels
Seller
Follow
mandy11149
Content preview
PEPTIC ULCER TREATMENT(1) Describe the principles of peptic ulcer disease therapy
• Therapeutic principles
• Remove irritants e.g. NSAIDs
• Symptomatic relief
• Acid suppression
• Helicobacter pylori eradication; Test and treat. Prevention of relapse and complications
• Ulcer healing
• Must consider the increased risk of gastric carcinoma
Factors causing Ulceration
• Helicobacter Pylori infection
• NSAIDs
• Nicotine can cause an increase in acid secretion
(2) List the potential areas of the parietal cell peptic acid secretion control that can be
targeted by drugs in both predisposing and treating peptic ulcer disease
• Peptic Ulcers; defect in gastric/duodenal mucosa due to imbalance in the peptic acid
secretion and gastroduodenal mucosal defence
• The gastric mucosa is the mucous membrane layer of the stomach which contains
gastric glands
• The gastric glands contain parietal cells; secrete HCL
• Drugs target this area
(3) Compare proton pump inhibitors with histamine2-receptor antagonists in terms of
mode of action, efficacy and adverse effects
• Treatment
• Antacids; reduces pain associated with the ulcer (aluminium
and Mg salts used)
• Neutralises acid with alkali.
• Produce symptomatic relief by raising gastric pH and reducing proteolytic activity
• Milk shouldn’t be used
• Sodium bicarbonate can cause alkalosis
• Proton Pump Inhibitors (PPIs); 'PRAZOLE': ome, lanso, panto,
esome
• Caution; Other drugs that end in prazole aren't always PPIs
• Reduce the amount of acid in the stomach
• MOA; blocks the gastric proton pump (H/K/ATPase)
• 1st line agent in Peptic ulcer disease and reflux oesophagitis e.g. GORD
• Omeprazole; indicated in peptic ulcer disease and reflux oesophagitis e.g. GORD
• Very effective and relatively well tolerated in the short term
• They can mask gastric cancer
• Common Adverse effects; GI disturbance and headache
• Important Adverse Effects; Increased risk of clostridium difficile infection (chronic use
may change the microbiome), low Na and Mg levels (electrolyte balance issues; also
caused by diuretics)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller mandy11149. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.89. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
75323 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now