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CPJE Top 400 Drugs & Doses Exam Questions and Answers
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CPJE Top 400 Drugs & Doses ExamQuestions and Answers
Tylenol - -Acetaminophen
I: fever/pain
D: 325-650mg, max < 4000mg/day from all sources
*OD = liver damage, use NAC for antidote
-Ofirmev (IV) - -Acetaminophen
I: fever/pain
D: < 4000mg/day from all sources
*Can treat more severe pain
*OD = liver damage, use NAC for antidote
-NAC - -N-acetylcysteine
I: APAP overdose
-Bayer - -Aspirin
I: fever/pain/inflammation
D: 81-325mg qd
CI: pregnancy (esp 3rd trimester), OD = tinnitis
*BBW: COX-1 selectivity NSAID = GI bleed
-Motrin, Advil - -Ibuprofen
I: fever/pain/inflammation
Dose
-OTC: 200-400mg q 4-6 hrs
-Rx: 600-800 mg tid, max 3200mg/d
*BBW: COX-1 selectivity NSAID = GI bleed
-Naprosyn - -Naproxen, Aleve
I: fever/pain/inflammation
D:
-OTC: 220mg qd
-Rx: 250-550mg bid
*Higher GI side effects
*BBW: COX-1 selectivity NSAID = GI bleed
-Daypro - -Oxaprozin
I: fever/pain/inflammation
*Similar caution to piroxicam: high risk for GI tox and severe SJS
*BBW: COX-1 selectivity NSAID = GI bleed
-Voltaren - -Diclofenac (gel)
,I: pain/inflammation
Dose: AAA 2-4g QID
-Toradol - -Ketorolac
I: analgesia
D:
-IV/IM 30mg x 1, or 30mg QID (max 120mg/d)
-PO: 20mg once after IV or IM, then 10mg q4-6hr (max: 40mg/d)
*Max = 5 days of treatment
*Most GI toxic w/ piroxicam
*BBW: COX-1 selectivity NSAID = GI bleed
-Indocin - -Indomethacin
-I: fever/pain/inflammation, gout
-D: 25-50mg IR, 75mg BID CR
*High risk for CNS SE and GI toxicity
*BBW: COX-1 selectivity NSAID = GI bleed
-Clinoril - -Sulindac
*less common NSAID that may be better w/ reduced renal function
*BBW: COX-1 selectivity NSAID = GI bleed
-Relafen - -Nabumetone
I: fever/pain/inflammation
D: 1000-200mg qd or bid
-Feldene - -Piroxicam
I: fever/pain/inflammation
D: 10-20mg qd
*High risk for GI tox and severe SJS
*Most GI toxic w/ ketorolac
*BBW: COX-1 selectivity NSAID = GI bleed
-Mobic - -Meloxicam
I: fever/pain/inflammation
D: 7.5-15mg po (Max: 15mg/d)
*COX-2 selectivity NSAID: CV event (MI, stroke)
-Celebrex - -Celecoxib
I: fever/pain/inflammation
D: 200mg qd or BID
*lowest GI bleed risk but highest CV risk
*COX-2 selectivity NSAID: CV event (MI, stroke)
-Humira - -Adalimumab
I: arthritis, psoriasis, Crohn's, UC, etc
,D: 40mg SC every other week
*BBW: fatal infections, malignancy, TB
-Remicade - -Infliximab
I: arthritis, psoriasis, Crohn's, UC, etc
D: 3 mg/kg IV on weeks 0, 2 and 6, then q8w
*Delayed hypersensitivity reactions
*BBW: fatal infections, malignancy, TB
-Enbrel - -Etanercept
I: arthritis, psoriasis, Crohn's, UC, etc
D: 50mg SC weekly
*BBW: fatal infections, malignancy, TB
-Orencia - -Abatacept
I: arthritis
D: 500-1000mg IV at 0, 2 and 4 weeks, then qm, 125mg SC weekly
*NS only
*Warnings: malignancies, serious infections, may worsen COPD sx
-Kineret - -Anakinra
I: RA
D: 100mg SC qd
*Warnings: malignancies, serious infections
-Arava - -Leflunomide
I: DMARD
D: 100mg PO x 3d, then 20mg PO qd
*BBW: embryo-fetal toxicity, hepatotoxicity
*CI: pregnancy (must have negative preg test and 2 forms of birth control &
wait 2 yrs after DC to have kids)
-Azulfidine - -Sulfasalazine
I: DMARD
D: 500-1000mg qd, then 1000mg BID
*CI: sulfa allergy
-Rheumatrex - -Methotrexate
I: DMARD
D: 7.5-20mg once weekly (never daily for RA)
*BBW: hepatotoxicty, myelosuppression, mucosititis/stomatitis
-Plaquenil - -Hydroxychloroquine
I: DMARD
D: 400mg qd, then 300mg qd
*Warnings: irreversible retinopathy
, -Imuran - -Azathioprine
I: RA, transplant
D: 1.5-3mg/kg/d IV or PO
*BBW: increased risk of malignancy in IBD
*Warning: hematologic toxicity, increased risk of myelosuppression in TPMT
pts
-Veetids - -Penicillin VK
I: infection
D: hella
*Renal toxicity
-Dynapen - -Dicloxacillin
I: staph infection
D: 125-500mg q6h PO
-Unasyn - -Ampicillin/sulbactam
D: 1.5-3 g q6h
*NS only
-Principen - -Ampicillin
D: 250-500mg po q6h, 1-2g IV q4-6h
*Empty stomach
*NS only
-Amoxil, Moxatag - -Amoxicillin
D: 250-500mg q8-12h,
500-875 q12h
*Take w/ food
-Augmentin - -Amoxicillin/clavulanic
D: 875/125mg po q12hr
*Take w/ food
-Zosyn - -Piperacillin/tazobactam
D:
-3.375 g QID IV
-4.5 TID-QID
-3.375-4.5g IV TID (each dose infused over 4 hrs)
-Ancef - -Cefazolin
1-2g q8hr IV/IM
*1st gen
-Ancef, Kefzol - -Cefazolin
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