Chapter 45, Menopause and Andropause Drugs TEST BANK INTRODUCTORY CLINICAL PHARMACOLOGY 12TH EDITION By Susan M Ford

1. A nurse is preparing to administer goserelin to a client with prostate cancer. Which assessment findings should the nurse prioritize on the ongoing assessment? A) Breast atrophy, sexual dysfunction B) Pharyngitis, asthenia C) Breast tenderness, edema D) Hyperglycemia, leukocytosis Answer: A Rationale: Breast atrophy and sexual dysfunction may be seen as adverse reactions of goserelin therapy. Pharyngitis and asthenia are seen with the useof anastrozole. Breast tenderness and edema are seen with drugs such as estramustine. Hyperglycemia and leukocytosis are seen as adverse reactions of mitotane. Question format: Multiple Choice Chapter: 45 Learning Objective: 2 Cognitive Level: Apply Client Needs: Physiological Integrity: Pharmacological Therapies Integrated Process: Clinical Problem-solving Process (Nursing Process) Reference: p. 617, Summary Drug Table 2. A nurse is preparing to administer oxybutynin to a client and discovers the client is also prescribed haloperidol. The nurse predicts the client has the increased risk of which reaction related to the concomitant use of both drugs? A) Decreased effect of haloperidol B) Increased risk for bleeding C) Lowered plasma concentrations D) Increased effect of oxybutynin Answer: A Rationale: The nurse should observe for decreased effectiveness of the antipsychotic drug (haloperidol) in the client as the effect of the interaction of the antispasmodic drug (oxybutynin) and haloperidol. Increased risk for bleeding results from the interaction of oral anticoagulants with anti-infective drugs. Increased effect of the antispasmodic drug occurs with the interaction of an antispasmodic drug with a tricyclic antidepressant. Plasma concentrations are lowered due to the interaction of fosfomycin, which is an anti-infective, with metoclopramide, which is used to relieve gastric upset. Question format: Multiple Choice Chapter: 45 Learning Objective: 2