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Samenvatting Metabole Systemen-Biochemie $6.95
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Samenvatting Metabole Systemen-Biochemie

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Een samenvatting van alle biochemie behandeld tijdens het vak metabole systemen. Zelf had ik dankzij deze samenvatting een 10 :)

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  • February 2, 2024
  • 6
  • 2023/2024
  • Summary
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DNA Schade , radicalen en energie metabolisme


DNA Schade Zuurstofradicalen : maken kleine veranderingen in eiwitten , lipiden nucleotiden


vorzaken worden gevormd in Mitochondria


endogeen : reacties met toxische stoffen (zuurstof radicalen) fouten tijdens replicatie
,
·



tijdens elektronen transport van oxidatieve fosforylering

vormen van straling chemische stoffen (asbest) als Oz een extra elektron opneemt
·



exogeen :
,




> UV-B straling leidt tot Thymine dimeren


schematisch overzicht energie metabolisme


Xeroderma pigmentosum : genetisch defect in nucleotide-excisie herstel


·

geen verwijdering van dimeren



gevolg : al tijdens jeugd plaveiselcelcarcinomen basaalcelcarcinomen en melanomen
·



,




van glucose tot ATP in 4 stappen



glycolyse (glucose < 4youvaat)

2
oxidatieve decarboxylering Pyruvaat <
acetyl CoA

3
Citroenzuurcyclus acetyl (oA > CO2


NADH uit C2C levert é aan elektrontransport Keten


Choog energetisch elektron

Citroenzuurcyclus oxidatieve fosfory leving

energie uit NADH zorgt voor de protongradiënt

ATP Synthase : maakt ATP uit ADP



~
gebruikt energie uit protongradiënt




oxidatieve stress : dysbalans tussen pro-oxidatieve a antioxidatieve processen te veel 02-radicalen


Cellen zijn Continu bezig met DNA-schade herstel door "excision-repair" dit Kost
,
veel energie




Vitamine ( & E zijn belangrijke antioxidanten

,

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