, A Text Book of
PATHOPHYSIOLOGY
(An Essential Guide for Pharmacy and Other Paramedical Courses)
As per PCI Regulations
B. Pharm. Sem. II
Dr. C. M. Jangme Mr. R. D. Wadulkar
M. Pharm., Ph.D. M. Pharm., (Ph. D.)
Principal, Department of Pharmacology,
Maharashtra College of Pharmacy, Channabasweshwar Pharmacy College,
Nilanga, Dist. Latur (MS). Latur, Dist. Latur (MS).
Mr. Shivakumar S. Ladde Dr. B. N. Poul
M. Pharm., (Ph. D.) M. Pharm., Ph. D.
H.O.D., Department of Pharmacology, Principal,
Shivlingeshwar College of Pharmacy, Maharashtra Polytechnic (D. Pharm) Institute,
Almala, Dist. Latur (MS). Nilanga, Dist. Latur (MS).
N3950
,PATHOPHYSIOLOGY ISBN 978-93-87397-99-6
Third Edition : February 2019
© : Authors
The text of this publication, or any part thereof, should not be reproduced or transmitted in any form or stored in any computer
storage system or device for distribution including photocopy, recording, taping or information retrieval system or reproduced on any disc,
tape, perforated media or other information storage device etc., without the written permission of Authors with whom the rights are
reserved. Breach of this condition is liable for legal action.
Every effort has been made to avoid errors or omissions in this publication. In spite of this, errors may have crept in. Any mistake, error
or discrepancy so noted and shall be brought to our notice shall be taken care of in the next edition. It is notified that neither the publisher
nor the authors or seller shall be responsible for any damage or loss of action to any one, of any kind, in any manner, therefrom.
Published By : Polyplate
NIRALI PRAKASHAN
Abhyudaya Pragati, 1312, Shivaji Nagar,
Off J.M. Road, PUNE – 411005
Tel - (020) 25512336/37/39, Fax - (020) 25511379
Email :
DISTRIBUTION CENTRES
PUNE
Nirali Prakashan : 119, Budhwar Peth, Jogeshwari Mandir Lane, Pune 411002, Maharashtra
(For orders within Pune) Tel : (020) 2445 2044, 66022708, Fax : (020) 2445 1538; Mobile : 9657703145
Email :
Nirali Prakashan : S. No. 28/27, Dhayari, Near Asian College Pune 411041
(For orders outside Pune) Tel : (020) 24690204 Fax : (020) 24690316; Mobile : 9657703143
Email :
MUMBAI
Nirali Prakashan : 385, S.V.P. Road, Rasdhara Co-op. Hsg. Society Ltd.,
Girgaum, Mumbai 400004, Maharashtra; Mobile : 9320129587
Tel : (022) 2385 9976, Fax : (022) 2386 9976
Email :
DISTRIBUTION BRANCHES
JALGAON
Nirali Prakashan : 34, V. V. Golani Market, Navi Peth, Jalgaon 425001, Maharashtra,
Tel : (0257) 222 0395, Mob : 94234 91860; Email :
KOLHAPUR
Nirali Prakashan : New Mahadvar Road, Kedar Plaza, 1st Floor Opp. IDBI Bank, Kolhapur 416 012
Maharashtra. Mob : 9850046155; Email :
NAGPUR
Nirali Prakashan : Above Maratha Mandir, Shop No. 3, First Floor,
Rani Jhanshi Square, Sitabuldi, Nagpur 440012, Maharashtra
Tel : (0712) 254 7129; Email :
DELHI
Nirali Prakashan : 4593/15, Basement, Agarwal Lane, Ansari Road, Daryaganj
Near Times of India Building, New Delhi 110002 Mob : 08505972553
Email :
BENGALURU
Nirali Prakashan : Maitri Ground Floor, Jaya Apartments, No. 99, 6th Cross, 6th Main,
Malleswaram, Bengaluru 560003, Karnataka; Mob : 9449043034
Email:
Other Branches : Hyderabad, Chennai
Note : Every possible effort has been made to avoid errors or omissions in this book. In spite this, errors may have crept in. Any type of error
or mistake so noted, and shall be brought to our notice, shall be taken care of in the next edition. It is notified that neither the publisher, nor
the author or book seller shall be responsible for any damage or loss of action to any one of any kind, in any manner, therefrom. The reader
must cross check all the facts and contents with original Government notification or publications.
| www.pragationline.com
Also find us on www.facebook.com/niralibooks
, Preface
Globally a pharmacist is a part of health care team and is therefore a health
practitioner. Understanding mechanisms of disease enables him to design and
implementation of clinical interventions which often prove effective in treatment of
disease. Pathophysiology is an integrative science that draws concepts from many basic
and clinical sciences, including Anatomy, Physiology, Biochemistry, Genetics, Cell and
Molecular Biology, Pharmacology and Biophysics. The general theoretical framework of
the subject Pathophysiology is based upon the theories and related concepts of adaptation
and homeostasis. An orientation to disease as disordered physiology can enable a student
to understand how and why the symptoms and signs of various conditions appear; the
need to understand the mechanisms underlying the disease and its clinical manifestations,
so that rational therapies can be devised.
Standard books on Pathophysiology to be taught in Pharmacy colleges, according to
the syllabi prescribed by Pharmacy Council of India (PCI) and respective Universities in
India were a long felt need. The vacuum created by the absence of such books has
resulted in hardship to the teachers, students and to the examiners as well.
Textbook of Pathophysiology (As per PCI): An Essential Guide for Pharmacy
and other Paramedical Courses is the first edition of the book. It emphasizes the
etiopathogenesis of diseases and disorders. In preparing this book, author's aim has
been, to satisfy the needs of the teachers and students of pharmacy colleges. Intended
readers are not only pharmacy students but also medical and paramedical students. They
will find the description of etiology, pathogenesis, pathology and pathophysiology of
disorders along with clinical manifestation and treatment. Readers will definitely
appreciate this book as a ready reference and refresher text. In particular, Pharmacy
students will welcome the format and scope of the book as a means of learning
pathophysiology. I am confident and sure that authors will find their endeavour fruitful as
they have fulfilled the purpose and all what they expected and intended to accomplish by
this book.
Outstanding features of book are:
• Detailed presentation of major disorders of all organ systems.
• Concise format, facilitating efficient use at all levels of pharmacy education.
• More than 50 major disorders and diseases are covered.
• Disease prevention and treatment information along with diagnosis.
• Organ system physiology elaborated for understanding physiologic process of diseases
• Glossary of key terms.
I earnestly ask for the co-operation of pharmacy teachers and students in suggesting
improvements in contents and if any one feels the necessity of making omissions,
corrections and verifications, it may be brought to authors notice so that the future
edition may be made more perfect.
Prof. (Dr) Nitin B. Ghiware,
Principal, Nanded Pharmacy College, Nanded
PATHOPHYSIOLOGY
(An Essential Guide for Pharmacy and Other Paramedical Courses)
As per PCI Regulations
B. Pharm. Sem. II
Dr. C. M. Jangme Mr. R. D. Wadulkar
M. Pharm., Ph.D. M. Pharm., (Ph. D.)
Principal, Department of Pharmacology,
Maharashtra College of Pharmacy, Channabasweshwar Pharmacy College,
Nilanga, Dist. Latur (MS). Latur, Dist. Latur (MS).
Mr. Shivakumar S. Ladde Dr. B. N. Poul
M. Pharm., (Ph. D.) M. Pharm., Ph. D.
H.O.D., Department of Pharmacology, Principal,
Shivlingeshwar College of Pharmacy, Maharashtra Polytechnic (D. Pharm) Institute,
Almala, Dist. Latur (MS). Nilanga, Dist. Latur (MS).
N3950
,PATHOPHYSIOLOGY ISBN 978-93-87397-99-6
Third Edition : February 2019
© : Authors
The text of this publication, or any part thereof, should not be reproduced or transmitted in any form or stored in any computer
storage system or device for distribution including photocopy, recording, taping or information retrieval system or reproduced on any disc,
tape, perforated media or other information storage device etc., without the written permission of Authors with whom the rights are
reserved. Breach of this condition is liable for legal action.
Every effort has been made to avoid errors or omissions in this publication. In spite of this, errors may have crept in. Any mistake, error
or discrepancy so noted and shall be brought to our notice shall be taken care of in the next edition. It is notified that neither the publisher
nor the authors or seller shall be responsible for any damage or loss of action to any one, of any kind, in any manner, therefrom.
Published By : Polyplate
NIRALI PRAKASHAN
Abhyudaya Pragati, 1312, Shivaji Nagar,
Off J.M. Road, PUNE – 411005
Tel - (020) 25512336/37/39, Fax - (020) 25511379
Email :
DISTRIBUTION CENTRES
PUNE
Nirali Prakashan : 119, Budhwar Peth, Jogeshwari Mandir Lane, Pune 411002, Maharashtra
(For orders within Pune) Tel : (020) 2445 2044, 66022708, Fax : (020) 2445 1538; Mobile : 9657703145
Email :
Nirali Prakashan : S. No. 28/27, Dhayari, Near Asian College Pune 411041
(For orders outside Pune) Tel : (020) 24690204 Fax : (020) 24690316; Mobile : 9657703143
Email :
MUMBAI
Nirali Prakashan : 385, S.V.P. Road, Rasdhara Co-op. Hsg. Society Ltd.,
Girgaum, Mumbai 400004, Maharashtra; Mobile : 9320129587
Tel : (022) 2385 9976, Fax : (022) 2386 9976
Email :
DISTRIBUTION BRANCHES
JALGAON
Nirali Prakashan : 34, V. V. Golani Market, Navi Peth, Jalgaon 425001, Maharashtra,
Tel : (0257) 222 0395, Mob : 94234 91860; Email :
KOLHAPUR
Nirali Prakashan : New Mahadvar Road, Kedar Plaza, 1st Floor Opp. IDBI Bank, Kolhapur 416 012
Maharashtra. Mob : 9850046155; Email :
NAGPUR
Nirali Prakashan : Above Maratha Mandir, Shop No. 3, First Floor,
Rani Jhanshi Square, Sitabuldi, Nagpur 440012, Maharashtra
Tel : (0712) 254 7129; Email :
DELHI
Nirali Prakashan : 4593/15, Basement, Agarwal Lane, Ansari Road, Daryaganj
Near Times of India Building, New Delhi 110002 Mob : 08505972553
Email :
BENGALURU
Nirali Prakashan : Maitri Ground Floor, Jaya Apartments, No. 99, 6th Cross, 6th Main,
Malleswaram, Bengaluru 560003, Karnataka; Mob : 9449043034
Email:
Other Branches : Hyderabad, Chennai
Note : Every possible effort has been made to avoid errors or omissions in this book. In spite this, errors may have crept in. Any type of error
or mistake so noted, and shall be brought to our notice, shall be taken care of in the next edition. It is notified that neither the publisher, nor
the author or book seller shall be responsible for any damage or loss of action to any one of any kind, in any manner, therefrom. The reader
must cross check all the facts and contents with original Government notification or publications.
| www.pragationline.com
Also find us on www.facebook.com/niralibooks
, Preface
Globally a pharmacist is a part of health care team and is therefore a health
practitioner. Understanding mechanisms of disease enables him to design and
implementation of clinical interventions which often prove effective in treatment of
disease. Pathophysiology is an integrative science that draws concepts from many basic
and clinical sciences, including Anatomy, Physiology, Biochemistry, Genetics, Cell and
Molecular Biology, Pharmacology and Biophysics. The general theoretical framework of
the subject Pathophysiology is based upon the theories and related concepts of adaptation
and homeostasis. An orientation to disease as disordered physiology can enable a student
to understand how and why the symptoms and signs of various conditions appear; the
need to understand the mechanisms underlying the disease and its clinical manifestations,
so that rational therapies can be devised.
Standard books on Pathophysiology to be taught in Pharmacy colleges, according to
the syllabi prescribed by Pharmacy Council of India (PCI) and respective Universities in
India were a long felt need. The vacuum created by the absence of such books has
resulted in hardship to the teachers, students and to the examiners as well.
Textbook of Pathophysiology (As per PCI): An Essential Guide for Pharmacy
and other Paramedical Courses is the first edition of the book. It emphasizes the
etiopathogenesis of diseases and disorders. In preparing this book, author's aim has
been, to satisfy the needs of the teachers and students of pharmacy colleges. Intended
readers are not only pharmacy students but also medical and paramedical students. They
will find the description of etiology, pathogenesis, pathology and pathophysiology of
disorders along with clinical manifestation and treatment. Readers will definitely
appreciate this book as a ready reference and refresher text. In particular, Pharmacy
students will welcome the format and scope of the book as a means of learning
pathophysiology. I am confident and sure that authors will find their endeavour fruitful as
they have fulfilled the purpose and all what they expected and intended to accomplish by
this book.
Outstanding features of book are:
• Detailed presentation of major disorders of all organ systems.
• Concise format, facilitating efficient use at all levels of pharmacy education.
• More than 50 major disorders and diseases are covered.
• Disease prevention and treatment information along with diagnosis.
• Organ system physiology elaborated for understanding physiologic process of diseases
• Glossary of key terms.
I earnestly ask for the co-operation of pharmacy teachers and students in suggesting
improvements in contents and if any one feels the necessity of making omissions,
corrections and verifications, it may be brought to authors notice so that the future
edition may be made more perfect.
Prof. (Dr) Nitin B. Ghiware,
Principal, Nanded Pharmacy College, Nanded
