What is the most common pediatric cancer? Correct Ans - Acute
lymphocytic Leukemia
Wilms tumor, retinoblastoma, and neuroblastoma are some cancers that
appear due to what etiologic factor? Correct Ans - Genetic basis
What type of cancer is more commonly seen with Down syndrome?
Correct Ans - Leukemia
Why are immunodeficient children more likely to develop malignancy?
Correct Ans - Cannot destroy cancer cells
What percentage of childhood cancers result from a predisposition in the
embryo? Correct Ans - Over 90%
CHILDREN acronym Correct Ans - C: continual weight loss, fatigue
H: headaches w vomiting (mornings)
I: increased edema or pain
L: lump or mass
D: development of whitish in pupil
R: recurrent fevers, night sweats
E: excessive bruising or bleeding
N: noticeable pallor
What is the peak onset of leukemia? Correct Ans - Between 2 and 5
years old
Is leukemia more frequent in males or females older than 1? Correct
Ans - Males
How many cases of leukemia are seen per 100,000 white children younger
than 15? Correct Ans - 3 to 4
Bone marrow starts proliferating immature blast WBCs; cellular
destruction takes place with infiltration and competition for metabolic
elements Correct Ans - Leukemia patho
, Which organs are most affected by leukemia? Correct Ans - Liver
and spleen
Anemia, infection, bleeding; spleen, liver, and lymph nodes show
infiltration, enlargement, and fibrosis Correct Ans - Consequences
of leukemia
What are clinical manifestations of leukemia? Correct Ans - Fever,
long bone pain, pallor, bruising
What test can suspect leukemia? Correct Ans - CBC with differential
How is leukemia diagnosed? Correct Ans - Bone marrow aspirate,
lumbar puncture
Where is bone marrow aspirate test done? Correct Ans - Out of iliac
crest, local anesthetic
How is the child positioned for bone marrow aspirate test? Correct Ans
- Side lying, hold still
What is the goal for treatment of cancer? Correct Ans - Rid body of
malignant cells aka CURE
How many phases of chemo are used for treatment of leukemia?
Correct Ans - Three
What is the induction phase of chemotherapy? Correct Ans - 1st;
Reduce tumor burden to undetectable level
What phase of chemo eradicates any residual leukemic cells? Correct
Ans - Consolidation phase (2)
What phase of chemo maintains control? Correct Ans -
Maintenance (3)
When would a child require intrathecal or radiation therapy? Correct
Ans - If leukemic cells get into spinal fluid
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