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Résumé jonctions cellulaires

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illustration des jonctions cellulaire

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  • February 5, 2024
  • 5
  • 2023/2024
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Tight jonction (ZO) : Desmosomes : 30-50 nm

actine Desmocoline
cinguline ZO1 occludine Desmoplakine Plakoglobine Desmogleine
actine ZO2 claudine MEC C2 Fi Desmoglée MEC
Desmoplakine Plakoglobine Desmocoline
Desmogleine



• transport cellulaire PLAQUE
DESMOSOMALE
• perméable a l'eau + sub dissoutes
• necessite une ZA pour se mettre en place
• cadhérine homophile
• aspect pentalamellaire MET
• pls / cellule
• transport paracellulaire par relachement des claudines

• présent dans crtn type de cellules (epithelliale,
• marquée par une crete jonctionelle
nb: desmogléine / desmocioline = Cadhérine

mémo : Claudine adore aller au zoo voir les singe et les otaries
claudine actine ZO cinguline Occludine

• hyper phosphorylation caténine β : dessablemblage de jonction :
passage select de metabolites
Zonula adhérence (ZA) : 15-20 nm • lié au terminal web lui meme lié au cmplx actine / myosine
• intervention dans la contraction muscu


actine prot de liaison Caténine β Caténine P120
Cadhérine E (CAM )--------
Ca2+
MEC
a

• calcium dep
• cadhérine
• caténine P120: Fixation Cadh E = Stabilisation
• caténine β :ancrage?

, GAP jonction
• C° calcium Dépendant
• Septalamellaire
Gap jonction : 2-3 nm • Seule jonction sans aucun lien avec ctsq
- Ca2+
• jonction uniquement par connexines : 0 P de liaison
6 connexines = 1 connexons = 1 hémicanal ----- 1hémicanal =1 conexons = 6 connexines
• passage molecules < 1000 DA
gap jonction
• ≈ 20 connexines
• 6 connexine = 1 connexons = 1 hémicanal
1 hémicanal•1hémicanal
A ++ Ca2+ C2 •
couplage electro-ch
circu libre d'ions, sens gradient= conductance des 2©
• couplage important en contraction muscu avc Ca2+
couplage métabolique
• passage peptides = partage de ressource inter-cell
• passage metabolites : ATP
• reseau d'info, AMPc IP3
Hémidesmosomes :
F1
condition d'un canal fermé :
Desmoplakine Desmoplakine
◦ p* connexines par Kinase
plakoglob plakoglob
◦ ++ taux Ca2+ IC
i i i i
n n n n ◦ - - pH IC
t t t t un taux de Ca2+ trop elevé = connexine de GAP entouré par
e e e e le complexe calmo-calcium --> fermeture du canal
g g g g
r r r r
i i i i
n n n n
e e e e
α β α β hémidesmosome:

Ca2+ Laminine


le
Mg2+
Col 4
• calcium / magnésium dependant
col 7 col7 col7 • !! porteines apparentées à desmoplakine et plakoglobine
col 1



MEC

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