Summary
Samenvatting Schema van alle antifungale medicatie
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Schema van alle antifungale medicatie besproken in de lessen van Cos. Zie ook bijhorend deel 3 mycologie.
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Naam Soort Werking Structuur Spectrum Administratie ExtraAmphotericin Polyenes Interactie met ergosterol: Lactonen + • Breed: gisten, schimmels • IV • Nefrotoxisch: AMB voorkeur voor
B (AMB) lipofiel ➔ zal binden met lipofiel amofiele binden op cholesterol ➔
deel AMB ➔ hydrofiel deel AMB componenten + opstapelen in de nier
aan de binnenkant ➔ vorming mycosamine • Kritisch AF
van poriën ➔ osmotische
disbalans
Miconazole Azoles Interferentie ergosterol Imidazoles of • Breed: gisten, • Zalf, oraal,.. • Squaleen ➔ lanosterol ➔
synthese: inhibitie C14- triazoles dermatophyten,… ergosterol
demethylase* ➔ geen
ergosterol + opstapelen
lanosterol
Caspofungine Echinocandins Inhibitie β-1,3-D-glucan Groot, cyclische • Smal: candida en • IV • Fungicidaal
synthetase (celwand)➔ cel lyse lipopeptiden aspergillus • Erge infecties
Terbinafine Allylamines Inhibitie squaleen epoxidase* Napthaleen ring + • Dermatophyten • Zalf, oraal • Squaleen ➔ lanosterol ➔
➔ opstapelen squaleen + geen aminegroepen • Aspergillus ergosterol
ergosterol • Fungistatisch
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