Summary
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Prof Geert Callewaert
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phaedralocquet
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HF7: ZICHT1. Het oog:
Blinde vlek:
- Zien we niks
o Geen fotoREC
- Oogzenuw verlaat oogbol
o Nervus optius visuele iortex
FotoREC op netvlies:
- Kegeltjes
o Vooral op fovea
o Lage liihtgevoeligheid – veel liiht nodig
o Detailziiht – hoge resolute
- Staafes
o Vooral op perifere retna
o Hoge liihtgevoeligheid – weinig liiht nodigµ
o Kleur - grijswaarden
Retna = fovea perifere retna
Retina
= laag versih iellen
- Retinale pigmeeneepige eel: sihermt
retna af
- Fotoreieptoren: kegeltjes & staafes
o Buitenste segm in pigmentepith
o Synaptsih iontait met bigpolaigre
cellen
Bipolaire iel synaptsih
iontait met manmligoncellen
Ganglioniellen synaps met
optisc e zenwh
- Horizontale iellen:
- Aeacrigene cellen:
o Regelen beide synaptsihe
overdraiht tss de element
o Filteren & moduleren
Belangrijkste iellen v retna: fotoREC – bipolaire iellen – ganglioniellen
!AP enkel in ganglioniellen
!Reieptorpotentaal in fotoREC & bipolaire iellen
Fototransduite:
- In buitenste segm v fotoREC
- Liiht dwars doorheen laag v iellen vooraleer je fotoREC kan prikkelen
o Liiht in 1 riihtng
o AP in andere riihtng
(tekening kegeltje/staafe zie iursus)
, Verdeling v kegeltjes & staafjes
- Fovea = uitsluitend kegeltjes
- Perifere retna =
vnl staafes beetje kegeltjes
Staafjes:
RPE = retnaal pigmentepitheel
OS = optsihe sihijven
o Buitenste segment: transduite vindt plaats
Zit vol: R odopsigne & eransdwcigne & …?
o W iontnue aangemaakt (onderaan) & afgebroken
(bovenaan)
CC = Convecting cilium
IS = binnenste segment
o Klassieke ielliihamen vd iel
S = synaps
o Met bipolaire iel
o NT voor fotorREC = mlweaeaae
RPE = retinaal pigmentepitheel
FUNCTIE:
- Fagoiytose
o Afreken v optsihe sihijven (bovenaan)
Rhodopsine:
Retnal
o Bij liiht: iis trans-retnal
Retnal dissoiieert van opsine
W geryileerd tot terug iis-retnal (via RPE)
Rhoposine w terug aangemaakt
Opsine
- Epitheeltransport (?)
o Vloeistof belangrijk
- Liihtabsorpte:
o Liiht komt binnen in oogbol prikkelt fotoREC
Moet dan geabsorb w dr pigmentiellen
Keert anders terug & prikkelt fotoREC 2x = niet bedoeling
( Naihtdieren: extra laag op epitheel: refeiteerd 2x prikkel)
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