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Aantekeningen hoorcollege 2: Protein structures & sequence profiles . Introduction to Bioinformatics $4.84   Add to cart

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Aantekeningen hoorcollege 2: Protein structures & sequence profiles . Introduction to Bioinformatics

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The notes from lecture 2 on Protein structures & sequence profiles for the course introduction to bioinformatics. The document contains clear images. Furthermore, it is organized and clearly marked.

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  • February 14, 2024
  • 4
  • 2023/2024
  • Class notes
  • Evert bosdriesz
  • Hoorcollege 2
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Introduction to bioinformatics
Hoorcollege 2 – 10 januari 2024
Protein structures & sequence profiles
Typical BLAST output
High scores are red, low score are black. Colors for alignment score
Proteins to below
Length of the sequence (4000). It’s a query sequence
Matching sequences are drawn below
From top to bottom there are sorted. Best alignment on top  Sorted by decreasing
alignment
Protein homologs are evolutionary related. Proteins look similar, because they started at the
same point


Possible output in more detail
Zoomed in
It’s a protein sequence, because there are more than 4 letters (all started by M)
Columns that are similar are highlighted, in a way they match the most
We want to recognize the conserved area’s / similar parts (*)
Protein family that is found in different species
Some are highly variable / some conserved, other don’t
Proteins that are conserved, is for a reason, called function
Common ancestor  all sequence? What happens in between?
- Mutation happens randomly
- Over a long time, in both parts same amount of mutations
- Natural selection  they died through an mutation
- Any mutation must be legal?
Running BLAST gives information about evolutionary


Summarize alignment, because there are big
Profiles are used  PSSM (position specific scoring matrix) is a type of profile
Sequence are down (amino acids)
To the right are the scores (sequence position)

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