- Volledig glomerulair geklaard
- !ook secretie thv tubulus
- Dus overschatting van GFR
- Urinair vol x urinaire conc creatinine / serumcreatinine x collectietijd
- Stijging serumcreatinine bij achteruitgang nierfunctie
- !aanmaak creatinine blijft niet constant: veroudering, chron nierlijden
Ureumklaring
- Volledig glomerulair geklaard
- !ook reabsorptie thv tubulus
- Dus onderschatting van GFR
eGFR
, - Opvolging evolutie nierfunctie
Beeldvorming
- Echo abdomen: grootte nieren, cortex dikte, stuwing, cysten, stenen, tumoren
- Doppler: bevloeiing nieren, a. renalis stenose, thrombose a./v. renalis
- RX abdomen: calcificaties
- CT/MRI
o !ioodhoudend contrast: acute deterioratie nierfunctie
o !gadoliniumcontrast: nefrogene syst fibrose (niet bij CKD stadium 4/5)
- Isotopenscan
o 99mTc-MAG3: bij hydronefrose
o 99mTc-DMSA: plaatselijke nierfunctie
Lok radioactiviteit
Opgenomen in tubulaire cellen
Procentuele functie L en R
Nierbiopt
- Onverklaard en belangrijk nierlijden
- !bloedingen, AV fistel
- CI
o Unieke nier
o Hoefijzernier
o Pyelonefritis
o Hypertensie
o Niet corrigeerbare stollingsfactoren
H2: acute nierschade, acute nierbeschadiging (acute kidney injury:
AKI)
- Acute vermindering excretiefunctie nier
- Stijging serumcreatinine
- Vermindering diurese
- Retentie uremische afvalstoffen
- Stoornissen elektrolyten, zuur/base, water
- Medische urgentie
- Symptomen
o Braken
o Anorexie
o Neurologische stoornissen (retentie uremische afvalstoffen)
- Voll urine-onderzoek
o Urinesediment
o Proteïne
o Creatinine
o Ionen
- Bloedonderzoek
o Ureum
o Creatinine
o Urinezuur
o Ph met bicarbonaat
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