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Samenvatting immunologie leerjaar 2 HLO deel 1 week 7
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Samenvatting immunologie leerjaar 2 HLO deel 1 week 7 (week 1t/m 6 is ook voor verkoop)
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Samenvatting week 7 immunologieOpdracht:
1. Waarom is het soms nodig om delen van extracellulaire eiwiten in HCI te krijgen?
- om CD8+ T cellen te actveren en diferenttren tot cytotoxtsche T cellen
2.welk celtype kan dit?
-alleen dendritsche cellen
3. Hoe gaat dat dan in zijn werk?
Kruispresentatie = zowel intra als extracellulaire eiwiten presenteren in CHI&II
normaal: antgeen van buiten opname, endolysosoom, HCII (zie samenvatng week 5)
actveren T-helper cellen.
-als je een cytotoxische reacte wilt actveren dmv extracellulaire eiwiten
, CD8+ T CEL ACTIVATIE
Signaal 1:
TCR + HC/peptde
Signaal 2:
co-stmulate
(bv.B7/CD28
Signaal 3:
cytokine signalen
(bv IL2 (TH1))
de cytokine signalen komen bij deze cellen dus van een
andere t-helper cel.
Bij de CD4+ cellen worden TH1 geactveerd > en nu actveerd
deze dus weer CD8.
Na actvate nog maar 1 signaal nodig = HCI
Hoeveel signalen nodig voor cytotoxische t-cel die geactveerd is? = 1
ECHANIS E VAN DODEN
1) Perforine > gaten in het membraan
granzyme B induceert apoptose (CAD =
caspase-actveerbaar desoxyribonuclease)
*intrinsic : iets in de cel brengen
2) Fas/FasL
extrinsic : apoptose inducte door receptor
interacte. Gaat niets in de cel.
B-CELLEN hfst.10
3 signalen nodig voor activatie B cel
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