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Summary YR 2 CONTENT
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Summary of 4 pages for the course Foundations Of Biomedical, Behavioural And Social Sciences For Medicine 2020/21 at UoS (YR 2 CONTENT)
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Infection as a mechanism of disease● Infection: colonisation of a pathogenic species, utilise the hosts resources to
reproduce and produce disease
● Caused by: viruses,bacteria,fungi,parasites
● Classified by symptoms,causative agent, medical signs
Symptoms=apparent infection
No symptoms= silent,subclinical
Inactive/dormant=latent
Principles of infection:
● Susceptibile host
● Host resistance
● Virulence and pathogenicity
● Control and transmission
Exogenously- bacteria in the environment
Endogenously-bacteria on ourselves-normal flora, injuries on skin
Routes of infection:
● Skin- keratinized barrier,low
pH,commensals
● Hair
● Eyes- fluid,eyelashes
● Respiratory- alveolar
macrophages,air flow,cilia,secretions
● GI- M cells, acid,secretions,bile,mucus
● GU-e,commensals
● Urinary tract-flushing,mucus,commensals
Direct/indirect contact
● Faecal-oral
● Sexually transmitted
● Verticle
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