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Summary

Sumario Acromegalia resumen

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resumen acerca del diagnostico y tratamiento de la acromegalia

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  • February 25, 2024
  • 2
  • 2023/2024
  • Summary
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ACROMEGALIA
DEFINICION:

Es la consecuencia clínica de la secreción de hormona somatotropa (Hormona
del crecimiento GH) después del cierre de los discos epifisiarios (la anomalía del
cierre de los discos epifisiarios y crecimiento lineal se denomina gigantismo).



ETIOLOGIA:

• El 95% son por Adenomas hipofisiarios (75% macro adenomas y 5% tumor
secretor de GHR en hipotálamo)
• La causa más común de acromegalia ectópica mediada por GHRN es el
tumor carcinoide abdominal (páncreas)

EPIDEMIOLOGIA:

• Asociado a pólipos pre malignos y cáncer de colon
• Incidencia en hombres de 40 a 45 años de edad
• Complicación más frecuente: Diabetes Insípida
• Hay elevación de la PRL hasta en un 25 – 40%

CLINICA:

• Cambio en las facciones
• Prognatismo
• Hiperhidrosis
• Voz grave
• SAOS
• Protuberancia frontal
• Macroglosia
• Artropatía
• Síndrome del túnel del carpo


Si hay compresión del quiasma óptico, puede producir Hemianopsia bitemporal y
cefalea.

Resistencia a la insulina (intolerancia a la glucosa)



DIAGNOSTICO:

• INICIAL: medición de factor decrecimiento similar a la insulina tipo 1 (IGF-1),
su incremento señala una posible acromegalia

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