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Samenvatting Biokatalyse H9-H15
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Hoofdstuk 9, Glycolyse & Gluconeogenese
Glycolyse Katabool
1
glucose - 2
Pyruvate + 2 ATP
Heeft geen 02 nodig
Gluconeogenese Anabool
Glucose
2
pyruvate + 2 ATP -
fermentatie-omzetten zonder 02
Vormt ethanol Lit Pyruvate
Complete O2 nodig
Oxidatie
Vormt CO2 + H20 mit pyruvate
Opname glucose Via Glut -12 transmembraan eiwit
in de cel
- .
Glucose bindt
. Ec kant
2 Sluit ,
IC kant opent
. Glucose komt
3
vrij in de cel
Actief darm mier verlies tegen
nodig in en om
glucose te
gaan
transport glucose ↳ via feces/4rine
via Sodium Glucose transporter ( = SGLT)
1
.
Na binet op Carrier
.
2 Hierdoor ontstaat plek om glucose te binden
.
3
Binding glucose Verandering Formatte van de Carrier
-
4. Mat komt veij 12 in Cytosol ,
Glucose volgt
5 .
Nat wordt actief weer uit de Cel gehaald
Hexokinase Start de glycolyse ,
induced-fit model
Houdt glucose in de Cel door Glucose te fosforyleeen 0 .
1 U
. . ATP
In de lever
glucokinase IPv hexokinase niet gevoelig voor inhibitie gluc-6-p
↳
sigmoidaal
, Glycolyse Fase 1
Voorbereidings
fase
Transferaserat
houdt glucose in de cel-
en gebruikt 1 ATP
Isomerase (5)
Transferase (2 7)
.
commited Step-
Hexokingse Houdt
glucose in cel door
fosforylatie 0 .
1. . v .
ATP
- giucoknase
-Herokinase
N
Transferase (2 7) ↳
-
.
allostorische Inhibitie door gluct-P -[glucose]
phosphogluco
Komerase
-
phosphofruct-Commited
O Step
(PfKt
I
Kindse
verbruikt 1 ATP
Transferase (2 70
.
wordt geinhibeerd door ATP
, Glycolyse Fase 2
b - 2 x 3C FRUC-1 6-Bip
1
IDHAP I
Tim
(GAp)
Glycolyse Fase 3
(
energ ie H ATP wordt gevormd
producerende
Fase 2 NADH H,
wordt
gevormd -
Geeft P
door
Dan ADD
I
+ D
2x
↑
, p-glycerate
mutase
Mechanisme
①
Tautomerisatie
pyRUVate
fot
1 f -
E
↑
- 4
T
x ro &
Wö
/
! ↳ ⑦
H Keto
end
Het lot van
Pyruvate
fermentatie-
ethanol
Fermentatie
pyruvate decarboxylase-lyase ,
co-factor is Thiamine pyrophosphate (Tpp)
Alcohol dehydrogenase
=
Oxidoreductase
*
NAD gevormd wordt terug gebruikt door 3-GAP dehydrogenase
Metto Reactie ColizO6 + 2 ADD + 2 pi
-
2 CH3CH2OH +
2 CO2 + 2 ATR
Duale Rol - .
ATP generatie
glycolyse
2 .
productie bouwstenen
, lactate /
fermentatie
Genotype IDH :
Hu :
lage km voor pyruvate
M Muscle wordt geinhibeerd door
pyruvate
· =
*
·
H =
Heart (en lever) in aerobe weefsels :
Veel NAD
IDH
Phenotype :
Mu :
Hoge kn voor
pyruvate
Tetrameer
·
In anderobe weefsels : Veel NADH
My MyH M2H2 MH3 H4 niet geinhibeerd door
·
,
, ,
,
pyruvate
Galactose Galactose
ADP
ATP
+
Pi
*
Galactokinase
Galactose-p
VDP-glucose
& ⑭ actse
↑
in ease
*
UDP-Galactose
+
glucose 1 P -
-
4DP-galactose
4 epimerase
-
*
HDD-Glucose
fructose
lever
in Fructose
de lever
in
en vet
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