NURS 316 - Midterm - Athabasca University
Study Guide Graded A+
1). Alkylating agents
Ans: Chlorambucil (PO)
-Kills in ALL phases of cell cycle
-Reacts with DNA/RNA
-Best for slow growing cancers
Mostly IV
Given in cycles
Amifostine + Cisplatin
Mesna + Ifosfomide
Allopurinol
2). Antimetabolites
Ans: Methotrexate (IV, PO)
-Inhibit DNA synthesis by blocking thymidylate, DNA polymerase, or folic acid reductase
-In S phase of cell cycle
-Used in rapidly dividing cancers
Methotrexate crosses BBB
Leucovorin is given to counter adverse effects
3). Anti-neoplastic antibiotics
Ans: Doxorubicin (IV)
-Breaks DNA strands in G2/M phase
-For rapidly dividing cancers
-ALL parenterally
-Doxo&Daunorubicin are both taken up by heart/lungs so can be toxic
-Dexrazoxane is given as cardioprotective drug
PaperStoc.com Page 1 of 5
, 4). Mitotic inhibitors
Ans: Vincristine (IV)
-M phase
-Excreted in feces
-Can cause arrythmias
5). Hormone modulators
Ans: Tamoxifen (po)
-Block production or receptor sites of the sex hormone
-Toremifene raises calcium
-Menopausal symptoms
-Risk of bleeding with anticoagulants
1. Protein tyrosine kinase inhibitors - blocks enzyme needed for protein building
2. Epidermal growth factor - enzyme found in tumors
3. Proteasome inhibitor - proteasome causes tumour growth
7). Salicylates
Ans: Aspirin (po)
-Inhibits prostaglandin synthesis and TXA2
-Salicylism toxicity 20g for adults, 4g for children
8). Nsaids
(propionic acid)
Ans: Ibuprofen
-Works by blocking inflammatory processes COX1 and COX2
PaperStoc.com Page 2 of 5
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Academik001. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $12.49. You're not tied to anything after your purchase.
