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Test Bank For Pharmacology and the Nursing Process 10th Edition By Linda Lilley Shelly Collins Julie Snyder Chapter 158 Complete Guide Newest Version 2023 $19.49   Add to cart

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Test Bank For Pharmacology and the Nursing Process 10th Edition By Linda Lilley Shelly Collins Julie Snyder Chapter 158 Complete Guide Newest Version 2023

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Test Bank For Pharmacology and the Nursing Process 10th Edition By Linda Lilley, Shelly Collins, Julie Snyder Chapter 1-58 |Complete Guide Newest Version 2023 The pKa (for the COOH group) of each of the three drugs is as follows: thyroxine = 3.0, mesothyroxine = 4.0, neothyroxine = 5.0. Of these, ...

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Test Bank for Pharmacology and the Nursing
Process 10th Edition By Linda Lilley, Shelly
Collins, Julie Snyder Chapter 1-58 |Complete
Guide 2022

1). The pka (for the cooh group) of each of the three drugs is as follows: thyroxine = 3.0,
mesothyroxine = 4.0, neothyroxine = 5.0. of these, which will be absorbed to the greatest
extent from the stomach (ph = 1.0)?

 Ans: neothyroxine


2). The multi drug resistance proteins (or p-glycoproteins) can protect liver and kidney cells by
exporting harmful chemicals against a concentration gradient in an energy-dependent
manner. what is this called?

 Ans: active transport


3). Phase ii conjugates typically have the following property/properties

 Ans: rapidly excreted in the urine


4). A drug with a half-life of 2 hours is administered by continuous intravenous infusion. how
long will it take for the drug to reach 50% of its steady state concentration?

 Ans: 2 hours


5). Caffeine is eliminated primarily by metabolism and with first order kinetics. the half-life of
caffeine varies significantly with individuals, but is on average 5.0 hours. the volume of
distribution is 0.60 l/kg. joe has a mass of 70 kg and is an average subject with regard to
caffeine pharmacokinetics. he has a regular habit of consuming a cup of coffee (85 mg of
caffeine) at 8 am.
what is the clearance value (cl) of caffeine in a normal individual?

 Ans: 0.083 L/hr/kg


6). Which of the following routes is most likely to be affected by the first-pass effect?




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,  Ans: oral


7). A drug, given as a 150 mg single dose, results in a peak plasma concentration of 10 ug/ml.
the apparent volume of distribution is (rapid distribution and negligible elimination prior to
measuring the peak plasma level):

 Ans: 15 L


8). Which of the following are routes of drug clearance?
-renal
-sweat
-intestines

 Ans: all of the above


9). What factor(s) may reduce drug bioavailability?
-gastric acid instability
-first-pass affect
-exposure to digestive enzymes

 Ans: all of the above


10). What type of receptor is the muscarinic receptor?

 Ans: G-protein coupled receptor


11). For a cholinesterase modified by an organophosphate compound (e.g. soman), what is the
time-dependent dealkylation process called yielding an enzyme refractory toward
reactivation?

 Ans: aging


12). Muscarinic receptors bind

 Ans: acetylcholine


13). Which of the following is a clinical use for a muscarinic agonist?

 Ans: "switching on" the urinary tract after surgery




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, 14). Indirect cholinergic agonists cause

 Ans: inhibition of acetylcholinesterase and a corresponding increase in the synaptic
acetylcholine levels


15). Which of the following is characteristic of the sympathetic nervous system?

 Ans: responded predominate during physical activity or when experiencing fright


16). A patient with an acute attack of glaucoma is treated with pilocarpine. the primary reason
for its effectiveness in this condition is its:

 Ans: ability to lower intraocular pressure


17). Put the following steps in the correct order for neurotransmission at the cholinergic
neuron

 Ans: 1. acetylcholine is synthesized from choline and acetyl-CoA
2. acetylcholine is released from storage vesicles into the synaptic cleft
3. acetylcholine is synthesized from choline and acetyl-CoA
4. acetylcholine is degraded by acetylcholinesterase


18). The autonomic nervous system innervates all of these except

 Ans: skeletal muscle


19). A soldiers' unit has come under attack with a nerve agent. the symptoms exhibited are
skeletal muscle paralysis, profuse brachial secretions, miosis, bradycardia, and
convulsions. the alarm indicates exposure to an organophosphate. what is the correct
treatment?

 Ans: administer atropine and 2-PAM (pralidoxime)


20). A study examining how a drug is distributed throughout the body and how the drug is
changed before eliminated is an example of

 Ans: pharmacokinetics


21). Knowing that all three drugs interact with the same receptor, which drug is a competitive
antagonist?




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