NWI-BM001D Molecular and Cellular Neurobiology summary - Sam
18 views 1 purchase
Course
Molecular and Cellular Neurobiology (NWIBM001D)
Institution
Radboud Universiteit Nijmegen (RU)
It contains extra background information and example questions for each chapter for you to try to answer at the end. I am a Dutch student so there might be some spelling errors or Dutch words in there. The Tiesinga lecture is not entirely complete. I also made a Quizlet:
,Which neurotransmitters are neuromodulatory? And which are inhibitory or excitatory?..........47
Which neurotransmitters are neuromodulatory? And which are inhibitory or excitatory?..........47
Deduce the different functions of cell adhesion molecules at synapses.........................................47
Deduce the different functions of cell adhesion molecules at synapses.........................................47
Describe the different stages of synapse formation and funciton, and the role of SCAMs in each
of these stages...........................................................................................................................................47
Describe the different stages of synapse formation and funciton, and the role of SCAMs in each
of these stages...........................................................................................................................................47
Give examples of SCAMs and their funcitonal domains.....................................................................47
Give examples of SCAMs and their funcitonal domains.....................................................................47
Schematically draw SCAMs to illustrate how they function...............................................................47
Schematically draw SCAMs to illustrate how they function...............................................................47
Explain what SNARE proteins are, and which SNARE proteins are involved in synaptic vesicle
exocytosis...................................................................................................................................................47
Explain what SNARE proteins are, and which SNARE proteins are involved in synaptic vesicle
exocytosis...................................................................................................................................................47
Schematically draw the functional domains of the SNARE proteins involved in SV exocytosis, as
well as the assemble SNARE complex....................................................................................................47
Schematically draw the functional domains of the SNARE proteins involved in SV exocytosis, as
well as the assemble SNARE complex....................................................................................................47
Describe the SNARE/SM protein cycle...................................................................................................48
Describe the SNARE/SM protein cycle...................................................................................................48
Describe how chaperones support SNARE protein function, and explain how their dysfunction
results in neurodegeneration..................................................................................................................48
Describe how chaperones support SNARE protein function, and explain how their dysfunction
results in neurodegeneration..................................................................................................................48
Explain the mechanisms by which calcium controls neurotransmitter release.............................48
Explain the mechanisms by which calcium controls neurotransmitter release.............................48
Describe the structure of the three groups of synaptotagmins........................................................48
Describe the structure of the three groups of synaptotagmins........................................................48
Explain which synaptotagmins function as synaptic calcium sensors for neurotransmitter
release and how this has been discovered and demonstrated........................................................48
Explain which synaptotagmins function as synaptic calcium sensors for neurotransmitter
release and how this has been discovered and demonstrated........................................................48
Explain how complexin and synaptotagmin function together to mediate calcium-induced
synaptic vesicle exocytosis......................................................................................................................48
, Explain how complexin and synaptotagmin function together to mediate calcium-induced
synaptic vesicle exocytosis......................................................................................................................48
Describe the events that occur between an incoming action potential at the presynaptic
terminal and synaptic vesicle exocytosis...............................................................................................48
Describe the events that occur between an incoming action potential at the presynaptic
terminal and synaptic vesicle exocytosis...............................................................................................48
Describe the different endocytic pathways that can be used for synaptic vesicel recycling........48
Describe the different endocytic pathways that can be used for synaptic vesicel recycling........48
Explain the methods that can be used to study sV endocytosis and infer which method is best
sutied for a given experimental quesiton.............................................................................................48
Explain the methods that can be used to study sV endocytosis and infer which method is best
sutied for a given experimental quesiton.............................................................................................48
List the sequential steps of clathrin-mediated endocytosis, the different classes of molecules
involved, and give examples of molecuels............................................................................................49
List the sequential steps of clathrin-mediated endocytosis, the different classes of molecules
involved, and give examples of molecuels............................................................................................49
Describe three pool models and how they function...........................................................................49
Describe three pool models and how they function...........................................................................49
Explain the methods to study synaptic vesicle pools and apply to a given scientific question....49
Explain the methods to study synaptic vesicle pools and apply to a given scientific question....49
Name the classical vesicular and plasmamembrane NT transporters.............................................49
Name the classical vesicular and plasmamembrane NT transporters.............................................49
Explain how nT transporters function, including their driving forces and their role in
neurotransmitter cycle.............................................................................................................................49
Explain how nT transporters function, including their driving forces and their role in
neurotransmitter cycle.............................................................................................................................49
Infer how NT transporters can modulate synaptic strength..............................................................49
Infer how NT transporters can modulate synaptic strength..............................................................49
Explain the effects of drugs that act on plasma membrane NT transporters (PMNTTs) and how
genetic mutation in PMNTTs may lead to disease...............................................................................50
Explain the effects of drugs that act on plasma membrane NT transporters (PMNTTs) and how
genetic mutation in PMNTTs may lead to disease...............................................................................50
How is it possible that vesicular neurotransmitter transporters are able to pump
neurotransmitters from the cytoplasm (where neurotransmitter concentration is relatively low)
into the synaptic vesicles (where neurotransmitter concentration is high)? What fuels this
process?......................................................................................................................................................50
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller sammievanboxtel. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.85. You're not tied to anything after your purchase.