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Samenvatting cellen hoofdstuk 8: Celverbindingen, 1e bachelor biomedische wetenschappen $7.77   Add to cart

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Samenvatting cellen hoofdstuk 8: Celverbindingen, 1e bachelor biomedische wetenschappen

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Samenvatting cellen hoofdstuk 8: Celverbindingen Biomoleculen & cellen 1e bachelor, 2e semester Biomedische wetenschappen

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  • March 18, 2024
  • 4
  • 2021/2022
  • Summary
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Samenvatting cellen: hoofdstuk 8 Celverbindingen

Gelijkaardige cellen zijn gegroepeerd in weefsels die de organen vormen -> gespecialiseerde
verbindingen nodig + cellen staan in contact met een complex netwerk van gesecreteerde
extracellulaire macromoleculen = extracellulaire matrix

4 types celverbindingen:

 Hechtingsverbindingen: verbinden cellen met elkaar en met extracellulaire matrix
 Afsluitende verbindingen: vormen selectief ondoordringbare cellaag
 Kanaalvormende verbindingen: faciliteren direct intercellulair transport van kleine moleculen
(=communicatieverbinding)
 Signaaloverdragende verbindingen: chemische of immunologische synapsen
(=communicatieverbinding)

CEL-CELADHESIE -> transmembraanproteïnen

Hoge turnover via exo- en endocytose zorgt voor de assemblage van adhesie complexen

Adhesieproteïnes fungeren als assemblage voor signaalcomplexen en cytoskeletaire structuren

 Directe relatie extracellulaire interacties, celvorm, celbeweging en signaaltransducties

Moleculen voor cel-cel interacties:

 Cadherines
 Selectines
 Integrines
 Cel adhesie molecule (CAM’s)

gaan interactie aan met ligand op oppervlak van naburige cel:

 Homofiele interactie: interagerende moleculen tussen de 2 cellen zijn identiek
 Heterofiele interacties: interagerende moleculen tussen de 2 cellen zijn verschillend




CAM’s

 Behoren tot de immunoglobuline familie -> lusvormige structuren
 N-CAM: homofiele interacties, andere: heterofiele interacties

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