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Samenvatting histopathologie: Long, 2e bachelor biomedische wetenschappen
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Samenvatting histopathologie: Long 2e bachelor, 1e semester Biomedische wetenschappen
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lottehulselmans
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Pathologie van de longLONGKANKER
Ontstaat in luchtwegen, soms in alveoli = alveolair carcinoom
Chemische prikkel (vb. sigaret) -> epitheel wordt beschadigd en verkeerd heropgebouwd (plaveisel)
Invasief carcinoom = epitheel wordt doorbroken
Symptomen:
Chronische hoest
Bloed ophoesten
Koorts
Pijn
Behandeling:
Chirurgie
Bestraling
Chemotherapie
Immunotherapie
Targetted therapie
Klassificatie:
Small cell lung cancer (SCLC): neuro-endocriene origine
Non-small cell lung cancer (NSCLC): epitheelcel is basiscel
klassificatie zorgt voor:
Prognose: Hoe lang gaat patiënt nog leven? -> vergelijken met voorgangers
Behandeling: Wordt gepersonaliseerd
Pathogenese: Uit welke cel ontstaat het?
Epidemiologie
Screaning is moeilijk: kan niet makkelijk aan bronchiolen geraken -> zeer invasieve methode met
buisje door de neus naar longen
Non-small cell lung cancer
Plaveiselcelcarcinoma (SCC)= tumor met plaveiselepitheel -> differentiatiegraad = hoe hard
lijkt de tumor nog op de moedercel? Vb: ongedifferentieerde tumor: niets te herkennen,
enkel dat cellen dicht op elkaar liggen
Papillair
Heldercellig
Kleincellig
Basaloid: lijkt op basale epitheelcellen
>90% rokers, meestal mannen
Ontstaat centraal, tumoruitbreiding: vaak locoregionaal
Genetica: EGFR gen mutatie, K-RAS, Her2 …
Adenocarcinoma: kliertype, kan klierbuizen vormen en individueel slijm vormen
Acinair
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