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Samenvatting immunologie les 3: De ontstekingsreactie, 2e bachelor biomedische wetenschappen
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Samenvatting immunologie les 3: De ontstekingsreactie 2e bachelor biomedische wetenschappen Prof. Ebo
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lottehulselmans
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Immunologie: Les 3: De ontstekingsreactieLokale ontstekingsreactie
Er kan enkel een ontsteking ontstaan in gevasculariseerd weefsel!
Lokale ontstekingsverschijnselen: calor / rubor / tumor / dolor / functio laesa
4fasen: werkt als 1 continum
1. Hyperemie: extravasatie door vaatverwijding Calor, rubor
2. Exsudatie: exsudaat door toename permeabiliteit Tumor, dolor, functio laesa
3. Infiltratie: meer neutrofielen en monocyten door diapedese -> activatie
endotheel/chemotaxis(cellen van intra naar extracell.)
4. Reparatie:
- Restitutio: volledig herstel zonder litteken
- Genezing door fibrosering: weefselschade vervangen door weefselschade -> litteken
- Chronische ontsteking: opruiming lukt niet -> granuloom
Exsudaat = weinig suiker, veel cellen
en eiwitten
Transudaat = veel suikers, weinig
cellen en eiwitten
Productie cytokinen door macrofagen en DC -> activatie mestcellen en macrofagen -> histamine,
bradykinine en stikstofoxide komen vrij -> vaatverwijding + stroomsnelheid bloed neemt af +
verhoogde permeabiliteit endotheel
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