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BIOC39 Midterm MCQ Questions and Answers
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BIOC39 midterm with 33 MCQ questions with prof Brunt.
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.1 econdary lymphoid tissue includes all of the following except:Bone marrow
S
2. The lectin pathway is complement activation is induced by:Mannose-binding lectin
3. A circulating naive B cell expresses ____ on the cell surfaceIGM and IGD
4. Which of the following describes two recombination signal sequences required for a
permitted somatic recombination event? H = heavy, k = kappa, l =lamdaVh
7-12-9::9-23-7jh
5. An important advantage of having two gene loci (k and A) for the light chain isThat
the likelihood of a successful rearrangement of light-chain genes increases
6. Antibody-dependent cell-mediated cytotoxicitiy (ADCC) is carried out by _____ after
cross-inking of IgG1 or IG3 antibodies on ______receptorNK cells; FcgRIII
7. Which of the following is correctly matched?pre-B-cellreceptor: VpreBlambda5
8. Which of the following immune responses is most beneficial in clearing parasite
infection in the intestinal tract?Production of IgE
9. How many complementarity-determining regions contribute ot the antigen binding
site in a B-cell receptor6
10.the granulocyte-macrophage progenitor gives rise to all of the following except:
Megakaryocyte
11.What is the fate of centrocytes in which somatic hypermutation has resulted in
high-affinity receptors for antigen?They processantigen and present it to CD8T cells
12.Which of the following characteristics of a large b-cell?VDJ is successfully arranged
13.The FcaRI receptor binds to ____-antigen complexes and facilitates the phagocytosis
of opsonized antigensMonomeric IgA
14.Which of the following is the predominant route by which pathogens are brought from
a site of infection into the lymph node?Afferentlymphatics
15.Order the following events of IG gene rearrangement
a. N-Nucleotides added by tdt
b. Rag genes recognize rss
c. Gaps filled by dna synthesis
d. Nuclease artemis generates p nucleotides
2413
16.Which of the following describes TI -2 antigens?Repetitiveepitomes
17.Which of the following is the membrane-bound from of C3 convertase of the
alternative pathway of complement activationC3bBb
18.The expression of the pre-B cell receptor is important for the cell to transition to
which stage of development?Small pre-B cell
19.Which of the following describe the flow of lymph through a lymph node draining an
infected tissue?Afff lymphatic vessel, Lymph node,efferent lymph vessel
20.Which of the following best describe the movement of a B cell through a LNEnter via
afferent lymphatic and exit via bloodstream
21.Which of the following is not a PAMP?Dsrna
22.Which of the following is not a feature of innate immunityLong-lasting immunological
memory
23.The five classes (isotyps) of immunologbins includeIgA, IgD, IgE, IgG, IgM
24.A protein epitope formed as a result of three-dimensional folding of the protein, and
which is destroyed if the protein denatures is called a ______ epitope.
Conformational
25.Which immunoglobulin is transported most efficiently across the mucosal epithelium?
Iga
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