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CS induced Acute Adrenal crisis.
Cause: adrenal insufficiency (CS use>14 days)
Dose tapering-when use exceed 14 days.
Suppression of HPA axis by exogenous GS
- Triggers: stress, surgery, trauma, infection
- Symptoms:
Mild: myalgias, malaise, anorexia, weakness
Severe: vomiting fever, hypotension, shock
Management: parenteral hydrocortisone
Preserve HPA axis -alternate day dosing or morning dose.
Physiological response and adverse effects
Inflammatory response Susceptibility to
infections
Cancer
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