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Summary Exam 2 Mood, Anxiety & Psychotic Disorders 2023/24

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This is an extensive summary of all the literature and lectures to be studied for the second exam of Mood, Anxiety & Psychotic Disorders year 2023/24. Marked in green are parts that I deemed especially important, but this is of course quite subjective.

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  • March 24, 2024
  • 76
  • 2023/2024
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Contents
Lecture 7: Acquisition of Fear.................................................................................................................3
History and basics of conditioning......................................................................................................3
Fear conditioning in the lab................................................................................................................4
Fear conditioning in the brain.............................................................................................................5
Criticism of traditional learning theory...............................................................................................5
Contemporary fear learning...............................................................................................................6
Fear acquisition and clinical fear and anxiety.....................................................................................7
Mineka & Zinbarg (2006): A Contemporary Learning Theory Persective on the Etiology of Anxiety
Disorders................................................................................................................................................8
Specific phobia....................................................................................................................................8
Social phobia....................................................................................................................................10
Panic disorder with and without agoraphobia..................................................................................10
Posttraumatic stress disorder...........................................................................................................12
Generalized Anxiety Disorder...........................................................................................................12
Obsessive-Compulsive Disorder........................................................................................................13
Conclusions.......................................................................................................................................14
Lenaert et al. (2014): Aversive learning and generalization predict subclinical levels of anxiety: A six-
month longitudinal study.....................................................................................................................14
Design...............................................................................................................................................15
Methods...........................................................................................................................................15
Results..............................................................................................................................................15
Discussion.........................................................................................................................................16
Lecture 8: Deconstructing fear memory: Extinction and reconsolidation.............................................17
Disrupting memory consolidation.....................................................................................................19
Craske et al. (2014): Maximizing exposure therapy: An inhibitory learning approach..........................20
Inhibitory learning model of extinction............................................................................................20
Deficits in inhibition and anxiety disorders.......................................................................................21
Inhibitory learning versus habituation and behavioral testing approaches to exposure...................21
Therapeutic strategies for enhancing inhibitory learning and retrieval............................................22
Therapeutic strategy for enhancing inhibitory regulation.................................................................24
Case studies......................................................................................................................................25
Elsey & Kindt (2017): Tackling maladaptive memories through reconsolidation: From neutral to
clinical science......................................................................................................................................27
Lecture 9: Intrusive Thinking................................................................................................................28

,Visser et al. (2020): Intrusive thinking across neuropsychiatric disorders: From molecules to free will
..............................................................................................................................................................29
Abstract............................................................................................................................................29
Introduction......................................................................................................................................30
What are the everyday manifestations of intrusions and their control?...........................................30
What are the main manifestations of intrusive thinking in mental health disorders?......................33
Revisiting the definition of intrusive thinking: A synthesis................................................................37
How to best study the processes underlying intrusive thinking and its control................................39
Summary of commonly used methods and desiderata for invesitgating intrusive thinking..............43
Lecture 10: The Psychology of Suicidal Behavior..................................................................................45
O’Connor & Nock (2014): The Psychology of Suicidal Behaviour..........................................................48
Introduction......................................................................................................................................48
Epidemiology....................................................................................................................................48
Multifactorial causes and the role of psychiatric disorders...............................................................49
Psychological theories of suicidal behaviour.....................................................................................49
Psychological risk and protective factors..........................................................................................51
Psychological treatment...................................................................................................................55
Key directions for psychological research.........................................................................................56
Lecture 11: Mood instability in the context of bipolar spectrum disorder............................................56
Broome et al. (2015): Mood Instability: Significance, Definition and Measurement............................59
Defining and measuring mood instability.........................................................................................59
Investigations and implications of mood instability..........................................................................59
Vannucci et al. (2022): Positive moods are all alike? Differential affect amplification effects of ‘elated’
versus ‘calm’ mental imagery in young adults reporting hypomanic-like experiences.........................60
Introduction......................................................................................................................................60
Method.............................................................................................................................................61
Procedure.........................................................................................................................................61
Measures..........................................................................................................................................61
Discussion.........................................................................................................................................62
Lecture 12: Distorted Reality: Psychotic Symptoms..............................................................................63
Kapur (2003): Psychosis as a State of Aberrant Salience: A Framework Linking Biology,
Phenomenology, and Pharmacology in Schizophrenia.........................................................................67
Dopamine as the “Wind of the Psychotic Fire”.................................................................................67
Dopamine as a Mediator of Motivatonal Salience............................................................................67
Psychosis as a Disorder of Aberrant Salience....................................................................................68
Dampening of Aberrant Salience by Antipsychotics..........................................................................69

, Implications and Predictions of This Model......................................................................................70
Relationship to Other Models and Ideas...........................................................................................70
Qualifications and Boundaries..........................................................................................................71
Hasson-Ohayon et al. (2017): The Special Challenges of Psychotherapy with Person with Psychosis:
Intersubjective Metacognitive Model of Agreement and Shared Meaning..........................................71
Constructing Agreement as an Intersubjective Process: Three Foundational Challenges in
Psychotherapy with Persons with Psychosis.....................................................................................72
Possible Paths for Resolutions of the Barriers to Agreement and Shared Meaning: Metacognition
and Empathy.....................................................................................................................................73
Summary, Conclusions and Additional Considerations.....................................................................74
Balter (2014): Talking Back to Madness................................................................................................75
Stress and vulnerability.....................................................................................................................75
Sandy’s CBT.......................................................................................................................................76

Lecture 7: Acquisition of Fear
Anxiety disorders:

 Very common;
 1/14 people worldwide affected.

Focus this lecture: early learning experiences.

History and basics of conditioning
Ivan Pavlov: classical conditioning.

 Aspects:
o Neutral stimulus (NS);
 Lead to OR.
o Orientation response (OR);
o Unconditioned stimulus (US);
 Leads to UR.
o Unconditioned response (UR);
 CS + US -> UR.
o Conditioned stimulus (CS);
 Leads to CR.
o Conditioned response (CR).

John B. Watson: fear comes from learning experiences.

 Contrast to existing view that fear is innate.
 ‘Little Albert’ study: loud noise (US) which the baby feared (UR) whenever baby began to play
(OR) with white rat (NS). This way, they trained the infant to fear (CR) the rat (CS).
o Illustrates Pavlovian (classical) conditioning.
o Generalization to other animals and objects.

Fear response (UR) shifts from aversive stimulus (US) to previously neutral stimulus (CS).

 Original view: CS – CR association;

,  Contemporary view: CS – US association.

Deconditioning (Mary Jones): ‘Little Peter’ – counter-conditioning study.

 Associative learning can also lead to unlearning of conditioned response.

Why does fear persist as CS is “harmless”?

 Two-process model (O.H. Mowrer):
o Fear acquisition: classical conditioning;
o Maintenance of fear: operant conditioning.
 Avoidance of feared object (CS) -> decrease fear -> increase in avoidance
behaviour.
 Prevents someone from learning that fear for CS is unfounded, and
so fear persists.

Fear conditioning in the lab
Animal research:

 Sound (CS) -> electric shock (US).
 CR: freezing.

Human research:

 Spider (CS) -> electric shock (US).
 CR: two ways of meauring.
o Subjective: US expectation;
o Physiological: startle response, skin conductance.
 Differential fear response: CS- used as control condition, then
compared to CS+.
o CS+ for 8 seconds, then US (shock);
o Startle probe right before US, height of anticipation (fear) to
US.
o CS- for 8 seconds, startle probe after 7 seconds, no US.
o After conditioning: US-expectancy higher for CS+ than for CS-.
 Indicative of fear learning.
o After conditioning: startle response stronger to CS+ than for CS-, and NA.
 Indicative of fear learning.
 Noise alone (NA) used to see if CS- is truly at baseline.




 Spider in hand is CS-.

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