Class notes
GWAS AND GENE NETWORK ANALYSIS
- Course
- Institution
detailed summary of how a GWAS and gene network analysis are done.
[Show more]
Seller
Follow
alarakayran62
Content preview
4- GWAS AND GENE NETWORK ANALYSISSunday, 1 October 2023 14:58
Variants in our genetics
Variants have different frequencies
Major allele reference
Minor alternative - minor allele frequency : to classify the variants
More than 99% of genomes when comparing two individyals are the sam e
Variants account for 0.6% of the difference btw individuals
Majority of the variants are SNPs
Mutation : actually a neutral term, where in medicine it is thought of as disease
Non-pathogenic variants (mutations) - changes in DNA sequence that do not have an effect o
disease
Pathogen (mutations) - impact on disease, rare in the population
Risk variants - may or may not impact disease but increase the risk of disease
Common variants are investigated in GWAS
Genotyping techniques
DNA microarrays
Varaints should be know in advance
DNA is cut into pieces
Pieces that are complementary to the probes will hybridize and remain on chip to emit light
Next gen sequencing (NGS)
GWAS
Used to identify common SNPs that are associated with a certain phenotype
2 populations : 1 phenotype of interest 2 without the phenotype
Association analysis to evaluate if some SNPs are common
Key words
P-value : prob of genotype-phenotype association
Effect size - beta : how strongly genotype-phenotype is associated
Odds ratio (OR): to represent effect size
Power: the ability of the analysis to identify a true association
After genotyping - association
,on
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller alarakayran62. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.33. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
60576 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now