Exam (elaborations)
2024 SKETCHY PHARMACOLOGY FOR STEP 1 EXAM QUESTIONS AND ANSWERS
- Course
- Institution
SKETCHY PHARMACOLOGY FOR STEP 1 EXAM QUESTIONS AND ANSWERS
[Show more]
Content preview
ENSKETCHY PHARMACOLOGY FOR STEP 1 EXAM
QUESTIONS AND ANSWERS
Ethosuximide MoA
ANSWER IS - block T-type Ca2+ channels in thalamic neurons
Methotrexate MoA
ANSWER IS - inhibit DHFR, reducing the amount of DHF reduced to THF, which reduces the amount of
thymine synthesized, which halts cells in S phase of mitosis
Methotrexate AE
ANSWER IS - Folate deficiency (megaloblastic anemia), myelosuppression, pancytopenia
Pulmonary fibrosis (dyspnea, bilateral diffuse opacities, honeycomb bronchioles)
Hepatotoxicity
Alopecia
Stomatitis, soreness of the mouth
5-FU MoA
ANSWER IS - metabolized to active form (F-dUMP), complexes with THF to inhibit thymidylate synthase,
which halts cells in S phase of mitosis
,EN
5-FU AE
ANSWER IS - diarrhea, photosensitivity, hyperpigmentation, myelosuppression (increased infxn risk)
Hydroxyurea MoA
ANSWER IS - blocks ribonucleotide reductase, preventing de novo thymidine synthesis, which halts cells
in S phase of mitosis
Hydroxyurea AE
ANSWER IS - myelosuppression/pancytopenia (increased risk of infxn)
Azathioprine MoA
ANSWER IS - prodrug of 6-mercaptopurine, a cytotoxic purine analog that decreases IMP, decreasing
DNA and RNA synthesis, halting cells in S phase
6-MP MoA
ANSWER IS - activated by HGPRT, active metabolites inhibit IMP synthesis, decreasing DNA and RNA
synthesis, halting cells in S phase
6-MP AE
ANSWER IS - myelosuppression (leukopenia, thrombocytopenia), reactivation of HZV, pancreatitis,
hepatotoxicity (liver enzyme monitoring required)
,EN
Mycophenolate mofetil AE
ANSWER IS - GI upset, myelosuppression, immunodeficiency
Mycophenolate mofetil MoA
ANSWER IS - IMP dehydrogenase inhibitor, decreasing AMP and GMP synthesis, decreased lymphocyte
production
Cladribine MoA
ANSWER IS - purine analog incorporated into DNA and inhibiting DNA Polymerase alpha and beta,
arresting cells in S phase
Cladribine use
ANSWER IS - myelosuppression
Cladribine AE
ANSWER IS - myelosuppression
Cyclophosphamide MoA
ANSWER IS - prodrug metabolized to active form by P450 to a DNA alkylating agent; cell-cycle phase
NON-specific
, EN
Cyclophosphamide AE
ANSWER IS - myelosuppression, hemorrhagic cystitis (dysuria, hematuria), increased risk for bladder
cancer, hyponatremia (SIADH-induction), infertility, premature menopause, irreversible aspermia
Cyclophosphamide rescue drug
ANSWER IS - Mesna
Busulfan MoA
ANSWER IS - alkylating agent that forms DNA intrastrand cross-links, preventing DNA replication and
causing apoptosis; cell phase NON-specific
Busulfan AE
ANSWER IS - lung toxicity (interstitial fibrosis), hyperpigmentation, myelosuppression
Nitrosoureas MoA
ANSWER IS - alkylating agents that require biotransformation in liver, cross BBB, and inhibit DNA
replication; non-cell cycle specific
Nitrosoureas AE
ANSWER IS - neurotoxicity (dizziness, convulsions, ataxia, etc)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Estudyr. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
71184 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now