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Samenvatting Weefsels H6: Bot
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Samenvatting gebaseerd op slides van professor Vral met bijhorende notities van in de les, alles wat je voor de theorie moet kennen van dit onderdeel.
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Samenvatting bind -ensteunweefsels: Bot
Inhoud
1.1 Inleiding............................................................................................................................................2
1.1.1 Indelingen..................................................................................................................................2
1.1.2 Lange been................................................................................................................................3
1.2 Samenstellende componenten.........................................................................................................3
1.2.1 Cellen.........................................................................................................................................3
1.2.1.1 Osteoprogenitorcel.............................................................................................................3
1.2.1.2 Osteoblasten.......................................................................................................................3
1.2.1.3 Osteocyten..........................................................................................................................4
1.2.1.4 Osteoclasten.......................................................................................................................4
1.2.2 ECM...........................................................................................................................................5
1.2 Lamellair bot.....................................................................................................................................6
1.3.1 Compact bot..............................................................................................................................6
1.3.2 Spongieus bot............................................................................................................................7
1.3 Plexiform bot....................................................................................................................................7
1.5 Botvorming – osteogenesis...............................................................................................................7
1.5.1 Directe botvorming....................................................................................................................7
1.5.2 Indirecte botvorming.................................................................................................................7
1.6 Histofysiologie van het bot...............................................................................................................9
1.7 Botregeneratie..................................................................................................................................9
1.8 Gewrichten.....................................................................................................................................10
1.8.1 Fibreuze gewrichten.................................................................................................................10
1.8.2 Kraakbenige gewrichten..........................................................................................................10
1.8.3 Synoviale gewrichten...............................................................................................................10
1
, 1.1 Inleiding
- Steunweefsel gekenmerkt door grote hoeveelheid anorganisch materiaal
o Ca++ hydroxy-apatiet kristallen
Ca10(PO4)6(OH)2
Gevormd in botmatrix
- Zeer druk en trekkrachtbestendig
- Specifieke architectuur met plaatsen voor
o Bloedvaten zorgen ervoor dat botcellen in matrix niet afsterven
o Zenuwelementen
- Levend cellulair weefsel + hoge metabolische activiteit
o Beïnvloedt door hormonen
o Permanente remodellatie bot wordt continu aangemaakt/afgebroken
Calcium heeft invloed op werking van cellen komt vrij wanneer bot moet
worden afgebroken
- Functie
o Steun
o Beweging
o Bescherming bv hersenen
o Bevatten beenmerg aanmaak bloedcellen
o Ca++ reserve
- Osteosarcoom = bottumor
- Secundaire metastatische tumoren
o = resultaat van ander type kanker( borst, prostaat …)
Verplaatsen zich via bloedbaan en veroorzaken botkanker
Tumorcellen verspreidt over hele lichaam
- Opbouw bot
o Calciummatrix
Enkel calcium bot zeer broos
o Collageenvezels
enkel collageen bot zeer buigzaam
- kleuring
o kalk uit botweefsel gehaald want anders te hard
slijpcoupes -->kalk nog aanwezig
ontkalken door zuur dat calcium doet neerslaan coupes maken
EDTA (ethyleen-diamino-tetra-azijnzuur)
o kleuren botmatrix bestaat vooral uit collageen eiwitten die positief geladen
groepen hebben kleurt met eosine roos
o kraakbeen kleurt met base (haematoxyline)
1.1.1 Indelingen
- Macroscopisch/anatomisch
o Compact bot
o Spongieus bot
- Microscopisch
o Primair/plexiform bot
o Secundair/lamellair bot
- Vorming
2
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