Summary
Samenvatting BIOCHEMIE (deel 2)
- Course
- Institution
Samenvatting BIOCHEMIE VAN DE INSPANNING JAAR gegeven door prof. CLARYS
[Show more]
Seller
Followthomasdemeersman
Content preview
Samenvatning Biochem envannden nspann niBIOCHEMIE
1 Inleiding
gelanir jkenafBrrniennz jn:
Afkorting Volledige naam
ATP AdenBs netr fBsfaat
AMP AdenBs nemBnBfBsfaat
PPi PyrBfBsfaat
PCr FBsfBiocrearne
Pi InBrian siochenfBsfBr
LDH LaioctaatdehydrBienase
CK Crearnek nase
PC FBsfBryliocrearne
AK Adenylaat-k nase
IMP InBs nemBnBfBsfaat
NH4+ AmmBn umn/nammBn ak
PCK FBsfBryliocrearnek nase
HK HexBk nase
PFK1 FBsfBfruioctBk nase
PK Pyruvaatk nase
PYR Pyruvaatn/npyrBdru venzuur
MZ Melkzuur
ALAT alan neam nBtransferase
gelanir jknBmntenweten:
o Verzurennvannsp erenn sne ienl jkneennBversiochBtnaannprBtBnen
2 Energetische substraten
o Versioch llendenb Biochem siochenprBiocessennhebbennATPnnBd inalsneneri eleveranioc er
PrBbleem:nvBBrraadnaannATPn snbeperkt
OplBss ni:nATPnwBrdtniehersyntherseerd
Snelhe dnh ervann snbepalendnvBBrndentenleverennprestare
Versioch llendenb Biochem siochenweiennBmnATPntenienereren
o DBBrntra n ninkunnenndezenbeïnvlBednwBrden
1
,Samenvatning Biochem envannden nspann ni
2.1 ATP
HydrBlysenvannATPnlevertneneri enBp
o 1mBlnATPnlevertn7,3nkiocalnBp
ATPnbestaatnu tn3nfBsfaatirBepenndewelkenverbBndennz jnndBBrn2nanhydr denb nd nien
o HydrBlysenvanndezenb nd niennsteltneneri envr j
V ndtnplaatsntussenn2denenn3denBfn1stenenn2denfBsfaatirBep
GevBlinvanndenhydrBlyse:nernwBrdtnAMPnennPP nievBrmd
DezenPP nkannBpnhaarnbeurtnBBkniehydrBlyseerdnwBrden
o D tnlevertn2nmBleioculennP nBp
VBBrnelkensBBrtnsp eriocBntraiocren snernhydrBlysenvannATPnnBd i
o D tnzBritnvBBrneneri enBmnaiocrne-nennmyBs nevezelsnBvernelkaarntenlatennil jden
Hanitnsamennmetndenwerk ninvannhetnenzymnmyBs ne-ATP-ase
Inndenioceln snernnBrmaalnmeernATPndannADPnaanwez i
o DezeniocBniocentrarenwBrdtnzBniBednmBiel jkniocBnstantniehBuden
GevBrmdnADPnmBetnsnelnteruinwBrdennBmiezetnBmnvBldBendenATPntenvBBrz en
InnmyBfbr llennz jnnern2nmeiochan smennd enh ervBBrn nstaan:
o V andenwerk ninvannPC
o V andenaiocrv te tnvannhetnenzymnadenylaat-k nase
Adenylaat-k nasen snaanwez in nnhetniocytBsBl
o ZBritnh ernvBBrndenBmzetninvannADPn nnATPnv anvBliendenreaiocre:
ADP+ ADP AK ATP+ AMP
⇔
DenievBrmdenAMPnspeeltneennbelanir jkenrBlnb jndenaiocrver ninvannanderen
enzymen
EiochterneennirBBtndeelnh ervannwBrdtnBmiezetndankz jndendeam nase-reaiocre:
AMP+ H AMP deaminase IMP + NH 4
→
DezenreaiocrenzBritnervBBrndatnnaneennhev ien nspann ninernsleiochtsneenn
beperktnensrji ninvannADPnennAMPn s
g jndezenreaiocrenBntstaatnIMPnennNH4+
o NH4+nwBrdtnmeteennieprBtBneerd
ZalnnaarndenleverniaannennwBrdtndaarnBmiezetntBtn
ureum
o IMPnwBrdtnBmiezetntBtnur nezuur
T jdensndenherstelper BdenwBrdtnIMPnBBknheelntraain
Bmiezetn nnAMP
Dezenreaiocren snBnBmkeerbaar
o D tnzBritnvBBrneennversiochu v ninnaarnreiochtsnvanndenBmkeerbaren
AK-reaiocre
Resultaatnh ervan:nverm nder ninvanndenBpstapel ninvan
ADPnenneennbl jvendnhBienATP/ADP-rarB
Wantn nd enndenhBeveelhe dnADPntenhBBinzBun
wBrdenn nndensp er,ndannzBundenATP-ase-
reaiocrenkunnennvertraien
Inneennrustendensp ernwBrdtnBnieveern1nm l mBlnATPnpernkinsp erweefselnpernm nuutnverbru kt
2
, Samenvatning Biochem envannden nspann ni
o T jdensnmax malen nspann ninwBrdtnBnieveern4nm l mBlnATPnpernkinsp erweefselnpern
seiocBndenverbru kt
HersynthesenvannATPn sndusnzeernbelanir jk
g jnsp eriocBntraiocrenwBrdtndusnATPnverbru kt
o DBBrnversioch llendenprBiocessen:
MyBs ne-ATP-asen(65ntBtn80%nvanndenATP)
Na/K-ATP-asenpBmpnBmnmembraanpBtenraalntenherstellenn(10%nvanndenATP)
Ca-ATP-asenBmnCa2+u tnhetniocytBsBlnennteruin nnhetnsariocBplasmarsiochnrerioculumnten
pBmpenn(20ntBtn30%nvanndenATP)
H erdBBrnstBptnhetnverbru knvannATPnn etnmeteennnanhetnstBppennvannden
sp eriocBntraiocre
2.1.1 De basale ATP-concentratie
HBeveelhe dnATPn nnnatnsp erweefselnsiochBmmeltntussenn4,5nenn6,7nm l mBl/kinsp erweefsel
Ernz jnnwe n inversioch llenntussenndensp erirBepen
Ernz jnnm n emenversioch llenntussenndensp ervezeltypes:
o HBierenwaardenn nnsnellensp ervezels
2.1.2 De ATP-concentratie tijdens inspanning
DenATP-iocBniocentrarenkBmtnnBB tnlaierndann60%nvannden n rileniocBniocentrarentenl iien
2.1.3 Het ATP-herstel tijdens inspanning
DBBrnhetnsnellenverbru knvannATPnenndenkle nen ntramusiocula renvBBrraadnaannATPnmBetndenhBeveelhe dn
ATPn nnfuniocrenvannhetnverbru knhersteldnwBrdenn
o Maarnd tn ntr ns eknhersteln snBnvBldBende
DaarBmnmBetnernvBBrndenresynthesenvannATPneennberBepniedaannwBrdennBpn
ntermed aren:
ReservesnaannPC
GlyiocBlyse
Ox darevenfBsfBryler ni
2.1.4 Het ATP-herstel tijdens recuperatie
Hetnhersteln snafankel jknvannden ntens te tnvannden nspann ni
o Intensen nspann ni:nherstelnrelarefntraai
15nm nutennnanden nspann nin n reelnATP-n veaunnBinsteedsnn etnbere kt
o Marien nspann ni:nherstelnrelarefnsnel
Enkelenm nutennnanden nspann nin n reelnATP-n veaunbere kt
EerstenbrBnnvannhersteln snhetnadenylaat-k nase-systeem
o Tenw jtennaanndenverhBBideniocBniocentraresnaannADPnennAMPnd enafnemen
Gebeurtnb nnennden30nseiocBndennnanhetnbei nd iennvanneenn nspann ni
2.2 Fosforylcreatine (PC)
FBsfBryliocrearnen snsameniesteldnu t:
3
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller thomasdemeersman. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $4.82. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
52355 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now