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Samenvatting BIOCHEMIE (deel 2)
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Samenvatting BIOCHEMIE VAN DE INSPANNING JAAR gegeven door prof. CLARYS
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Samenvatning Biochem envannden nspann niBIOCHEMIE
1 Inleiding
gelanir jkenafBrrniennz jn:
Afkorting Volledige naam
ATP AdenBs netr fBsfaat
AMP AdenBs nemBnBfBsfaat
PPi PyrBfBsfaat
PCr FBsfBiocrearne
Pi InBrian siochenfBsfBr
LDH LaioctaatdehydrBienase
CK Crearnek nase
PC FBsfBryliocrearne
AK Adenylaat-k nase
IMP InBs nemBnBfBsfaat
NH4+ AmmBn umn/nammBn ak
PCK FBsfBryliocrearnek nase
HK HexBk nase
PFK1 FBsfBfruioctBk nase
PK Pyruvaatk nase
PYR Pyruvaatn/npyrBdru venzuur
MZ Melkzuur
ALAT alan neam nBtransferase
gelanir jknBmntenweten:
o Verzurennvannsp erenn sne ienl jkneennBversiochBtnaannprBtBnen
2 Energetische substraten
o Versioch llendenb Biochem siochenprBiocessennhebbennATPnnBd inalsneneri eleveranioc er
PrBbleem:nvBBrraadnaannATPn snbeperkt
OplBss ni:nATPnwBrdtniehersyntherseerd
Snelhe dnh ervann snbepalendnvBBrndentenleverennprestare
Versioch llendenb Biochem siochenweiennBmnATPntenienereren
o DBBrntra n ninkunnenndezenbeïnvlBednwBrden
1
,Samenvatning Biochem envannden nspann ni
2.1 ATP
HydrBlysenvannATPnlevertneneri enBp
o 1mBlnATPnlevertn7,3nkiocalnBp
ATPnbestaatnu tn3nfBsfaatirBepenndewelkenverbBndennz jnndBBrn2nanhydr denb nd nien
o HydrBlysenvanndezenb nd niennsteltneneri envr j
V ndtnplaatsntussenn2denenn3denBfn1stenenn2denfBsfaatirBep
GevBlinvanndenhydrBlyse:nernwBrdtnAMPnennPP nievBrmd
DezenPP nkannBpnhaarnbeurtnBBkniehydrBlyseerdnwBrden
o D tnlevertn2nmBleioculennP nBp
VBBrnelkensBBrtnsp eriocBntraiocren snernhydrBlysenvannATPnnBd i
o D tnzBritnvBBrneneri enBmnaiocrne-nennmyBs nevezelsnBvernelkaarntenlatennil jden
Hanitnsamennmetndenwerk ninvannhetnenzymnmyBs ne-ATP-ase
Inndenioceln snernnBrmaalnmeernATPndannADPnaanwez i
o DezeniocBniocentrarenwBrdtnzBniBednmBiel jkniocBnstantniehBuden
GevBrmdnADPnmBetnsnelnteruinwBrdennBmiezetnBmnvBldBendenATPntenvBBrz en
InnmyBfbr llennz jnnern2nmeiochan smennd enh ervBBrn nstaan:
o V andenwerk ninvannPC
o V andenaiocrv te tnvannhetnenzymnadenylaat-k nase
Adenylaat-k nasen snaanwez in nnhetniocytBsBl
o ZBritnh ernvBBrndenBmzetninvannADPn nnATPnv anvBliendenreaiocre:
ADP+ ADP AK ATP+ AMP
⇔
DenievBrmdenAMPnspeeltneennbelanir jkenrBlnb jndenaiocrver ninvannanderen
enzymen
EiochterneennirBBtndeelnh ervannwBrdtnBmiezetndankz jndendeam nase-reaiocre:
AMP+ H AMP deaminase IMP + NH 4
→
DezenreaiocrenzBritnervBBrndatnnaneennhev ien nspann ninernsleiochtsneenn
beperktnensrji ninvannADPnennAMPn s
g jndezenreaiocrenBntstaatnIMPnennNH4+
o NH4+nwBrdtnmeteennieprBtBneerd
ZalnnaarndenleverniaannennwBrdtndaarnBmiezetntBtn
ureum
o IMPnwBrdtnBmiezetntBtnur nezuur
T jdensndenherstelper BdenwBrdtnIMPnBBknheelntraain
Bmiezetn nnAMP
Dezenreaiocren snBnBmkeerbaar
o D tnzBritnvBBrneennversiochu v ninnaarnreiochtsnvanndenBmkeerbaren
AK-reaiocre
Resultaatnh ervan:nverm nder ninvanndenBpstapel ninvan
ADPnenneennbl jvendnhBienATP/ADP-rarB
Wantn nd enndenhBeveelhe dnADPntenhBBinzBun
wBrdenn nndensp er,ndannzBundenATP-ase-
reaiocrenkunnennvertraien
Inneennrustendensp ernwBrdtnBnieveern1nm l mBlnATPnpernkinsp erweefselnpernm nuutnverbru kt
2
, Samenvatning Biochem envannden nspann ni
o T jdensnmax malen nspann ninwBrdtnBnieveern4nm l mBlnATPnpernkinsp erweefselnpern
seiocBndenverbru kt
HersynthesenvannATPn sndusnzeernbelanir jk
g jnsp eriocBntraiocrenwBrdtndusnATPnverbru kt
o DBBrnversioch llendenprBiocessen:
MyBs ne-ATP-asen(65ntBtn80%nvanndenATP)
Na/K-ATP-asenpBmpnBmnmembraanpBtenraalntenherstellenn(10%nvanndenATP)
Ca-ATP-asenBmnCa2+u tnhetniocytBsBlnennteruin nnhetnsariocBplasmarsiochnrerioculumnten
pBmpenn(20ntBtn30%nvanndenATP)
H erdBBrnstBptnhetnverbru knvannATPnn etnmeteennnanhetnstBppennvannden
sp eriocBntraiocre
2.1.1 De basale ATP-concentratie
HBeveelhe dnATPn nnnatnsp erweefselnsiochBmmeltntussenn4,5nenn6,7nm l mBl/kinsp erweefsel
Ernz jnnwe n inversioch llenntussenndensp erirBepen
Ernz jnnm n emenversioch llenntussenndensp ervezeltypes:
o HBierenwaardenn nnsnellensp ervezels
2.1.2 De ATP-concentratie tijdens inspanning
DenATP-iocBniocentrarenkBmtnnBB tnlaierndann60%nvannden n rileniocBniocentrarentenl iien
2.1.3 Het ATP-herstel tijdens inspanning
DBBrnhetnsnellenverbru knvannATPnenndenkle nen ntramusiocula renvBBrraadnaannATPnmBetndenhBeveelhe dn
ATPn nnfuniocrenvannhetnverbru knhersteldnwBrdenn
o Maarnd tn ntr ns eknhersteln snBnvBldBende
DaarBmnmBetnernvBBrndenresynthesenvannATPneennberBepniedaannwBrdennBpn
ntermed aren:
ReservesnaannPC
GlyiocBlyse
Ox darevenfBsfBryler ni
2.1.4 Het ATP-herstel tijdens recuperatie
Hetnhersteln snafankel jknvannden ntens te tnvannden nspann ni
o Intensen nspann ni:nherstelnrelarefntraai
15nm nutennnanden nspann nin n reelnATP-n veaunnBinsteedsnn etnbere kt
o Marien nspann ni:nherstelnrelarefnsnel
Enkelenm nutennnanden nspann nin n reelnATP-n veaunbere kt
EerstenbrBnnvannhersteln snhetnadenylaat-k nase-systeem
o Tenw jtennaanndenverhBBideniocBniocentraresnaannADPnennAMPnd enafnemen
Gebeurtnb nnennden30nseiocBndennnanhetnbei nd iennvanneenn nspann ni
2.2 Fosforylcreatine (PC)
FBsfBryliocrearnen snsameniesteldnu t:
3
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