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G protein coupled receptor notes
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exam questionG-protein coupled recepter
↳ Describe key steps in receptor signalling or signal transduction ?
Key sleps in
receptor signalling or
signal transduction
↳ when against drug bind to its receptor
C A
drug receptor complex is formed
↳
drug receptor complex under goes a conformational change
↳ This
trigger a chain of biochemical processes inside the cell >
-
biological response
of receptor
3
stager signalling process
↳ signal receptor + agonist drug bird to and activates a specific receptor on/inside the target cell -
↳ signal transduction >
-
drug receptor complex activals a series of relay protein
8 produces
2nd
messengers inside the cell
.
↳ cellular response -> eventually a cellular or biological response to the original drug binding signal
is triggered
① Receptor
② transduction
Extracellular Cytoplasm ③ Response
Fluid Receptor 11 (
&
E
g0
= = >
- Activation of cellular
signal tranduction pathway responses
II
question ↑ plasma
exam signal
membrane
molecule
↓ Describe majer signal transduction pathway & receptor super families
* O
4 Mojer Signal Transduction Pathway
↳ Activation of receptor-ion channels (ligand gated receptors)
↳ Activation of second merenger
pathway via G-protein-coupled receptors
↳ Activation of enzyme-linked receptor e
g Tyrosine Kinase linked receptors
.
C Direct activation of gene transcription via Intracellular receptor
of receptor molecular structure $ that
* Receptor superfamily- a
group with a similar basic
use the same signal transduction pathway .
* 4
Majer Receptor super families
↳ Ligand gated/con Channel linked receptor
↳ G-protein-coupled receptor
↳ Kinase linked receptor
↳ Intracellular/nuclear receptor
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