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Lecture notes ligand-gated ion channel
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ligand-gated ion channel superfamily Notes all those notes should prepare you for the written exam, good luck:)
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exam Question :Ligand-gated on channel
& Describe
* features/characteristics of Ligand-gatedion channel superfamily
↳ of conformational
binding ligand (neuro transmitter) =>
change in receptor protein =>
opening
of ion-permeable pore > flow of permeant ions
into/out of cell down their electrochemical gradient.
↳ in flow
through activated channel
= > modulation of cellular function.
↳ LGIs involved in wide range biological functions.
synaptic franission sh neural communications
e
g
.
cell excitation , muscle contraction s intracellular signalling.
question Describe
exam :
* basit for subclassification of
ligand-gated in channel families
↳
based on effect on membrane potential st cellular electrical
induced Channel
activity by ion flow
through open
* Excitatory ,
cation-selective LGIs => nAChR ,
S-HTzR
ionotropic glutamate (NMDA ,
AMPA & Kainate) receptors
& P2X receptors·
Mediate influx of cation= > membrane depolarisation
* inhibitory ,
anion-selective LGI +=> GABAAR$
glycine receptors exam question : Describe
↳ characteristic feature of major
- Mediate influx of anion
= > Membrane
hyperpolarisation .
Key
channel families
Ligand-gated ion
I
cys-loop Receptor family
-
pentameric :
composed of S subunits
- nAChR , S-HTsR , GABAAR ,
glycine receptors
-
Conotropic Glutamate Receptor family
Tetrameric
- composed : of 4 submit
-
NMDA ,
AMPA & Kainate receptor
③ 2X Receptor family
-
Trimeric :
composed of 3 subunits
-
P2x1 ,
P2X2 , P2X3 , P2X4 ,
P2X5 & P2X7
receptors
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