Exam (elaborations)
Introduction to enzymes lecture note
- Course
- Institution
Introduction to enzymes lecture note
[Show more]
1 review
By: Fordenken • 4 months ago
Content preview
Lecture 22- Enzymes of Diagnostic ImportanceLecture 22- Enzymes
of Diagnostic
Importance
, Lecture 22- Enzymes of Diagnostic Importance
What marker enzymes of diagnostics do we look for in the liver? What are
the names?: 1. Aspartate transaminase (AST)
1. Alanine transaminase (ALT)
2. Where are the liver enzymes localized, and describe their activity.:
Localization: ALT located in cytosol of hepatocytes exclusively; AST present in
cytosol and mitochondria of hepatocytes. It also expresses in muscle cells
(skeletal/cardiac muscles).
Activity: The activity of ALT in hepatocytes is very high when compared to AST 3.
What is the diagnostic importance of liver enzymes?: When liver cells are
damaged due to infections, inflammation etc (hepatitis, liver cirrhosis) abnormal
amounts of these 2 enzymes are released in the bloodstream. The levels of ALT
and AST serve as important markers of impaired liver function and play an
important role in assessing and monitoring the degree of hepatocyte damage in
the liver.
, Lecture 22- Enzymes of Diagnostic Importance
.
4. What is ALP? What are they important in? Where are they localized?
Where can they be present in high concentrations in?: Alkanline phosphatase
(ALP): is a group of enzymes that dephosphorylates proteins, nucleic acids and
alkaloids at a higher pH.
5. ALP as a SIGNIFICANT marker of what specific condition? Describe this
condition and its symptoms.: Cholestasis
6. In order to use enzyme markers for a clinical diagnosis, what must a
physician check for?Clinical Diagnosis of a Disease using Enzyme Markers:
1)
Presence/absence of marker enzymes in plasma/serum
2) Change in enzyme conc.: Plasma/serum/ cellular concentration (see if there
is a drastic change)
3) Change in enzyme localization-mitochondrial enzymes when mito is
damaged will be released into the blood 4) Pattern of enzyme clearance
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller QUALITYGRADES. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $12.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67096 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now