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kinase- linked receptor
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exam quain :Kinase-Linked receptor
↳ Describe
*
Key features/characteristic of enzyme -
or kinase-linked receptor superfamily
Binding of Ligand conformational transmitted transmembrane helix
change in receptor protein via
>
- -
·
intrinsic/associated .
carsade
>
- activation of an
enzyme >
- initiation of signaling
·
Mediate action of multiple growth factors , cytokine & hormones
play major roles in regulation of cell growth , proliferation
& differentiation
contain an intrinsic enzyme activity in their intracellular domain diverse super family of
associate > multi-subunit transmembrane
directly with an intracellular enzyme
.
protein complex either :
·
Focuse on
Type
1
family (Epidermal Growth factor Receptor)
·
regulator of critical cellular processes .
e
g
sell cycle control & cell migration , cell survival & metabolism
proliferation & differentiation .
initiation of
· contain intrinsic
tyrosine kinase domain - become active
upon ligand binding -
signalling cascades
key regulators of critical cellular process e.g proliferation & differentiation
cycle control cell survival s metabolism.
migration
cell & cell ,
of cell surface receptor that transduce signals to polypeptide & Protein
·
family
hormones & growth factors
↓ exam question Describe
:
basis for subclassification of kinate
enzyme
or
*
-
-
linked receptor
↳ Receptor Tyrosine Kinases e
g
.
IR , EGFR
-
contain intrinsic
tyrosin kinases
activity
↳ Receptor Serine/Threonine Kinases TGF-BR
eg
-
contain intrinsic serine/threonine kinases activity
↳ Tyrosine Kinase-Associated Receptor (Cytokine Receptor (
- Associate with protein that have tyrosine kinase activity
.
↳ Receptor Guanylyl Cyclones - ANPR
-
contain intrinsic cyclase activity
↳ Receptor Tyrotine Phosphatases
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