100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Nuclear Receptor $9.01   Add to cart

Class notes

Nuclear Receptor

 19 views  0 purchase
  • Course
  • Institution

All those notes should be enough to prepare for exams that linked to nuclear Receptor

Preview 1 out of 5  pages

  • April 5, 2024
  • 5
  • 2023/2024
  • Class notes
  • Boachie-ansah
  • All classes
  • Unknown
avatar-seller
exam qua :
Nuclear Receptor
f
Describe



Key
* features/characteristics of nuclear receptor superfamily
Super
↳ family of intracellular
VA-binding
BI transcription factor selectively bind
small molecule Lipophilic Ligandand transduce their signal into specific in
gene
expression

↳ located intracellularly (in cytosol or nucleus) & translocate to nucleus
upon ligand binding ->
recognize
& bind specific DNA element sequence regulatory region of
in of
target gene >
- control

transcription of target gene

↳ human NR
superfamily consist of 48 members includes receptor for steroid hormones , thyroid hormone,
vitamin A
,
vitamin D , fatty did cholesterol metabolites Oxystest

↳ NR are
=
monomeric protein that share a common structural architecture consisting of 5 main
domains :




· N-terminal (A/B) domain (NTD) -
harbours a
ligand-independent transcriptional
activation function-1 site


·

DNA-binding (C) domain (BD) -
mediates DNA recognition & Receptor binding
motifs each
comprises 2 "Zind
Finger"coordinating
-




containing
a zinc ion


fetrahedrally 4 cysteine residues .




Hinge (D) highly flexible link DBA to LBD
play role in receptor
·
region -


, ,

dimerization

harbours
ligand-binding(E) domain (LBD) ligand-binding site
·
-
a
or

pocket & a
Ligand dependent
-




transcriptional activation function-2 site
C-terminal
· (F) domain That modulates co-activator $
co-repressor binding
↳ harbours motifs with nuclear localisation signals
& binding sites for accessory heat
shock & other proteins.

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller ralromaimi. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $9.01. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

67866 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$9.01
  • (0)
  Add to cart