Class notes
Lecture autonomous nervous system2.0
- Course
- Institution
Lecture autonomous nervous system bbs
[Show more]
Seller
Follow
cc103169
Content preview
Lecture 4-12-2018 autonomous nervous system IIContent lecture
repetton of pharmacology
exercise: cardiac and vascular efects
efects of nicotne related drugs
o nicotne is toxicology
o aferent nerves
o eferent nerves
baroreceptors stmulaton
renal sympathetc denervaton
Exercise: sympathetc actvaton:
o Increase in cardiac output, redistributon of blood fow, tuning of organ
functon, increase in oxygen use.g
o Normal cardiac output: 5L/min; max cardiac output: 25 L/min
o Normal heart rate: 70 bpm; max 200 (-250) bpm
o Stoke volume 1.g5 a heart cannot double (In short term)
o Lungs take up more oxygen
o Blood is not going to the GI tract but to the lungs, heart and muscles.g
o Heart:
Coronary dilaton smooth muscle B2 receptors
Sympathetc nervous system: noradrenalin will stmulate B2-
receptors in the coronary arteries to dilate them.g
Tachycardia B1 receptors on sinus node
Heart rate goes up, that is a B1 efect.g n the Sinus node are
B1 receptors and they are stmulated by adrenaline and
noradrenaline.g
o Lungs:
Smooth muscle B2 receptors bronchodilaton
Adrenaline
Easier oxygen uptake (3x as much as normal), more blood
fows through the lungs.g
o GI tract:
Smooth muscle a1 receptors contract.g
Noradrenaline
Blood will not go through the GI tract but go to the urine
system (kidney)
Spleen is also contractng (spleen hurts when exercising)
, Noradrenaline
o Hemodynamic efects of inter
venously injecton of NA in a
computer simulaton
o There is an increase in blood
pressure.g
o Noradrenalin has a high infnity of
alpha receptors vasoconstricton
increase resistance higher
blood pressure.g
o Heart rate only goes up in higher
doses.g
o Affinity NA: alpha 1b beta 1 ; no
affinity for B2 receptors.g
You need more
noradrenaline to increase the heart rate
o Beta 1 increase in HR vasoconstricton: alpha1 increase in R
increase in BP.g
Adrenaline:
o Vasodilataton, increase in
heart rate and blood goes up
and down.g
o Affinity: A : beta 2 b beta 1 b
alpha 1 receptors leading to:
vasodilaton, tachycardia.g
o In low concentraton it will
only bind to B2 receptors:
Bronchodilaton and dilataton
of coronary arteries and
muscles.g
o When you give more
adrenaline, the heart rate
goes up.g
o When you give again more
adrenaline, it will also bind to
a receptors and cause
vasocontracton.g
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller cc103169. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.21. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67474 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now