100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Summary BHCS2005 Clinical Haematology and Biochemistry - Haematology Overview $11.23
Add to cart
Quickly navigate to
Preview
  2.  
  3. Plymouth University (UOP)
  4.  
  5. BHCS2005 - Clinical Haematology and Biochemistry (BHCS2005)

Summary

Summary BHCS2005 Clinical Haematology and Biochemistry - Haematology Overview
 0 purchase
  • Course
  • BHCS2005 - Clinical Haematology and Biochemistry (BHCS2005)
  • Institution
  • Plymouth University (UOP)

Haematology overview for the BHCS2005 module at the university of plymouth. DOES NOT CONTAIN ALL THE MODULE INFORMATION JUST AN OVERVIEW

Preview 2 out of 8  pages

Document information

  • April 17, 2024
  • 8
  • 2022/2023
  • Summary

Subjects

  • haematology
  • biochemistry
  • plymouth uni
  • bhcs2005

Written for

  • Plymouth University (UOP)
  • Unknown
  • BHCS2005 - Clinical Haematology and Biochemistry (BHCS2005)
All documents for this subject (2)

Seller

avatar-seller
hawkinsella2002

Reviews received

Content preview

Haematology


Blood Constituents
 Red blood cells
o Carry oxygen to tissues

 White blood cells
o Function primarily as defence to infection

 Platelets
o Primarily prevent blood loos by coagulation and clotting

 Plasma
o Transport medium for nutrients, plasma proteins, growth factors and
clotting factors


Erythropoiesis
 Life span of RBC is 100-120 days
 20 seconds to circulate
 Erythropoietin stimulates RBC production


Red Blood Cell
 Biconcave disc
 No nucleus
 Diffusion of O2 and CO2
 At the lungs, oxygen diffuses into the blood
o Oxygen reacts with and attaches to haemoglobin

o This oxygenation reaction with haemoglobin produces excess H+
ions which react with HCO3- to produce H2CO3
o The carbonic acid decomposes to CO2 which diffuses out of the
blood


Haemoglobin
 Per Hb molecule
o 2 alpha chains

o 2 beta chains

, o 4 heme groups carrying iron

 Each subunit 17kDa
 Heme
o Iron held in porphyrin ring

o Iron co-ordinates with 4 nitrogen

o Oxygen binds to Fe2+ to become oxygenated

o If Fe2+ becomes oxidised to Fe3+ so no longer able to bind to
oxygen


Oxygen Binding
 Sigmoidal curve
o Once oxygen binds, the next oxygen binds more readily due to
conformational change
 Oxygen tension at the placenta is lower than arterial pressure
o This means that foetal Hb (HbF) has a higher affinity to bind oxygen
at low pressure
o HbF can release oxygen at even lower pressure to ensure
oxygenation of foetal tissues
 Glycated HbA
o HbA can be glycated to give 3 forms

 A1a, A1b and A1c
 This is due to high plasma glucose levels
o Hb A1c is a indication of diabetes mellitus



Ontogeny
 Ontogeny is where haematopoiesis takes
 This takes place in the sternum, pelvis and femurs in the bone marrow
 It can also occur extramedullary in certain pathological conditions


Haematopoiesis
 Haematopoiesis is required for the production and development of blood
cells
 It is needed for
o Transport of oxygen

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller hawkinsella2002. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $11.23. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

66184 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 15 years now

Start selling
$11.23
  • (0)
Add to cart
Added