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The Complement System - All three pathways explained in detail with colorful diagrams!

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This pdf explains the complement system in detail. It covers Nomenclature of complement proteins, the Alternative pathway, the classical pathway, the lectin pathway, and the membrane attack complex.

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  • February 22, 2019
  • 15
  • 2017/2018
  • Class notes
  • Unknown
  • All classes
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The Complement System



The Complement
System




Learning Objectives
The complement system or complement
Nomenclature of complement proteins
The pathways of complement activation
The alternative pathway
The Lectin pathway
The Classical pathway
Terminal steps of complement pathways
Inflammation
All rights reserved. No part of this publication may be reproduced or utilized in any form or by any means,
electronic or mechanical, including Opsonization
photocopying, recording, or by any information storage and retrieval
system, without prior written permission from the publisher.
Contact Us – franklectures@gmail.com Formation of MAC

, The Complement System




The Complement
This complement activation further leads
System or Complement to three major consequences which help
_____________________________________
eliminate the pathogen.
The complement system or complement is

a set of plasma proteins which are made 1. Inflammation

constitutively by liver. They are present
2. Enhanced phagocytosis:
in blood, lymph and extracellular fluids. Opsonization

The complement system assists or 3. Destruction of pathogen by

complements the immune cells in cytolysis

destroying pathogens. Most of the
There are three complement
proteins of the complement system are
activation pathways:
proteolytic enzymes. In the absence of

infection, they circulate in inactive forms
1. The Alternative Pathway
(zymogens). Infection stimulates

complement activation which means the 2. The Lectin Pathway

inactive proteins become active. 3. The Classical Pathway

The complement proteins act in a cascade
Before going into the details of
which means one reaction stimulates
these pathways, let us understand few
another reaction, which further stimulates
important points regarding the
another and so on.
nomenclature of the complement system.




All rights reserved. No part of this publication may be reproduced or utilized in any form or by any means,
electronic or mechanical, including photocopying, recording, or by any information storage and retrieval
system, without prior written permission from the publisher.
Contact Us – franklectures@gmail.com

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