PMHNP I - Exam 1 - Psychopharmacology PMHNP I - Exam 1 - Psychopharmacology 100% Verified Review 2024

PMHNP I - Exam 1 - Psychopharmacology 100% Verified Review 2024 Psychotropic Medications - ANS-Antidepressants, antipsychotics, mood stabilizers, anxiolytics, hypnotics, stimulants Organized by structure MOA Distinguished by subtle differences in molecular structure. Most psychotropics are lipophilic and highly protein bound; thus, older adults have more body fat and less protein, more likely to develop toxicity. Pharmacology - ANS-Study of what drugs do and how they do it. Pharmacokinetics - ANS-What the BODY does to the DRUG (ADME) Pharmacodynamics - ANS-What the DRUG does to the BODY Time course and intensity of a drug's effect Drug MOA Therapeutic Index - ANS-Measure of a toxicity or safety of a drug The ratio of the median toxic dose to the median effective dose The median toxic dose is the dose at which 50% of patients experience a toxic effect If the therapeutic index is high, it is reflected by a wide range dosage of which the drug is prescribed (Haloperidol, Depakote) If the therapeutic index is low, careful monitoring of serum drug levels will be needed (Lithium) Suicidal Ideation and Antidepressant Tx - ANS-Higher risk up to age 24 in short term tx (4-16 wks) BBW Clozapine ADR - ANS-Agranulocytosis Lamictal ADR - ANS-SJS Nefazodone (Serzonel) ADR - ANS-Hepatic failure Phenelizine (Nardil) ADR - ANS-Stroke Thioridzaine (Mellaril) ADR - ANS-Heart Block Longterm Complication of DRA Haldol - ANS-Tardive dyskinesia; increased risk of breast CA (larger cumulative doses) Somnolence - ANS-Often an intended effect of many psychotropic drugs Treat insomnia, anxiety, or agitation Clinician should alert patient to use caution when driving or operating heavy machinery Management of somnolence can include: - Adjusting the time or dosing of medication - Switch to an alternative medication Continues...